| 9/4/2010 | Hartwick 31 @ Morrisville Mustangs 20 | |
| 9/11/2010 | Salve Regina Seahawks 19 @ Hartwick 20 | |
| 9/18/2010 | Hartwick 27 @ Norwich Cadets 42 | |
| 10/2/2010 | Hartwick 17 @ Ithaca Bombers 29 | † |
| 10/9/2010 | Alfred Saxons 35 @ Hartwick 14 | † |
| 10/16/2010 | Hartwick 14 @ St John Fisher Cardinals 41 | † |
| 10/30/2010 | Hartwick 20 @ Springfield Pride 39 | † |
| 11/6/2010 | Utica Pioneers 21 @ Hartwick 24 | † |
| 11/13/2010 | Mount Ida Mustangs 12 @ Hartwick 27 |