| 9/4/2010 | Illinois Wesleyan Titans 20 @ Hope 16 | |
| 9/11/2010 | Hope 14 @ Wisconsin Lutheran Warriors 17 | |
| 9/18/2010 | Hope 21 @ Millikin Big Blue 31 | |
| 9/25/2010 | Lakeland Muskies 27 @ Hope 12 | |
| 10/2/2010 | Alma Scots 0 @ Hope 38 | † |
| 10/9/2010 | Hope 35 @ Kalamazoo Hornets 24 | † |
| 10/16/2010 | Hope 14 @ Albion Britons 27 | † |
| 10/23/2010 | Trine Thunder 31 @ Hope 10 | † |
| 11/6/2010 | Hope 7 @ Adrian Bulldogs 33 | † |
| 11/13/2010 | Olivet Comets 7 @ Hope 14 | † |