| 9/4/2010 | Azusa Pacific Cougars 42 @ San Diego 14 | |
| 9/11/2010 | San Diego 3 @ Southern Utah Thunderbirds 32 | |
| 9/18/2010 | UC Davis Aggies 38 @ San Diego 24 | |
| 9/25/2010 | Butler Bulldogs 0 @ San Diego 24 | † |
| 10/2/2010 | San Diego 28 @ Jacksonville Dolphins 35 | † |
| 10/9/2010 | Dayton Flyers 21 @ San Diego 20 | † |
| 10/16/2010 | San Diego 14 @ Marist Red Foxes 10 | † |
| 10/23/2010 | Valparaiso Crusaders 10 @ San Diego 30 | † |
| 10/30/2010 | San Diego 17 @ Drake Bulldogs 38 | † |
| 11/6/2010 | Morehead State Eagles 0 @ San Diego 34 | † |
| 11/13/2010 | San Diego 29 @ Davidson Wildcats 15 | † |