| 9/3/2009 | Quincy 3 @ SE Missouri St 72 | |
| 9/12/2009 | SE Missouri St 3 @ Cincinnati 70 | |
| 9/19/2009 | Eastern Illinois 23 @ SE Missouri St 14 | † |
| 9/26/2009 | SE Missouri St 22 @ Tennessee-Martin 29 | † |
| 10/3/2009 | SE Missouri St 17 @ Tennessee St 23 | † |
| 10/10/2009 | Austin Peay 24 @ SE Missouri St 14 | † |
| 10/24/2009 | SE Missouri St 16 @ Tennessee Tech 28 | † |
| 10/31/2009 | SE Missouri St 6 @ Eastern Kentucky 20 | † |
| 11/7/2009 | Jacksonville St 24 @ SE Missouri St 3 | † |
| 11/14/2009 | Murray St 13 @ SE Missouri St 49 | † |
| 11/21/2009 | Southern Illinois 42 @ SE Missouri St 24 |