| 9/10/2009 | Pikeville 10 @ Tennessee Tech 51 | |
| 9/19/2009 | Tennessee Tech 7 @ Eastern Kentucky 17 | † |
| 9/26/2009 | Tennessee Tech 7 @ Kansas St 49 | |
| 10/3/2009 | Austin Peay 23 @ Tennessee Tech 31 | † |
| 10/10/2009 | Tennessee Tech 35 @ Tennessee-Martin 28 | † |
| 10/17/2009 | Tennessee Tech 15 @ Eastern Illinois 23 | † |
| 10/24/2009 | SE Missouri St 16 @ Tennessee Tech 28 | † |
| 10/31/2009 | Tennessee St 13 @ Tennessee Tech 20 | † |
| 11/7/2009 | Tennessee Tech 0 @ Georgia 38 | |
| 11/14/2009 | Tennessee Tech 28 @ Jacksonville St 55 | † |
| 11/21/2009 | Murray St 14 @ Tennessee Tech 45 | † |