| 9/3/2009 | Kentucky Wesleyan 10 @ Murray St 66 | |
| 9/12/2009 | Murray St 7 @ North Carolina St 65 | |
| 9/19/2009 | Murray St 10 @ Missouri State 35 | |
| 9/26/2009 | Eastern Kentucky 23 @ Murray St 13 | † |
| 10/10/2009 | Jacksonville St 41 @ Murray St 7 | † |
| 10/17/2009 | Murray St 9 @ Tennessee St 6 | † |
| 10/24/2009 | Murray St 24 @ Tennessee-Martin 38 | † |
| 10/31/2009 | Eastern Illinois 16 @ Murray St 10 | † |
| 11/7/2009 | Austin Peay 17 @ Murray St 27 | † |
| 11/14/2009 | Murray St 13 @ SE Missouri St 49 | † |
| 11/21/2009 | Murray St 14 @ Tennessee Tech 45 | † |