| 9/5/2009 | Missouri State 10 vs Arkansas 48 (Little Rock AR) | |
| 9/12/2009 | Tennessee-Martin 14 @ Missouri State 24 | |
| 9/19/2009 | Murray St 10 @ Missouri State 35 | |
| 9/26/2009 | Northern Iowa 35 @ Missouri State 7 | † |
| 10/3/2009 | Missouri State 17 @ Youngstown St 7 | † |
| 10/10/2009 | S Dakota St 24 @ Missouri State 17 | † |
| 10/17/2009 | Missouri State 17 @ Western Illinois 16 | † |
| 10/24/2009 | Missouri State 21 @ N Dakota St 17 | † |
| 10/31/2009 | Illinois St 24 @ Missouri State 14 | † |
| 11/7/2009 | Indiana St 7 @ Missouri State 31 | † |
| 11/14/2009 | Missouri State 24 @ Southern Illinois 44 | † |