| 9/1/2005 | #5 Oregon | 38 | @ | Houston | 24 | ||||
| 9/10/2005 | Sam Houston | 10 | @ | Houston | 31 | ||||
| 9/16/2005 | Houston | 41 | @ | UTEP | 44 | 2 OT | CUSA | ||
| 10/1/2005 | Houston | 30 | @ | Tulsa | 23 | CUSA | |||
| 10/8/2005 | Houston | 35 | @ | Tulane | 14 | CUSA | |||
| 10/15/2005 | Memphis | 35 | @ | Houston | 20 | CUSA | |||
| 10/22/2005 | Houston | 28 | @ | Mississippi St | 16 | ||||
| 11/5/2005 | Houston | 29 | @ | UCF | 31 | CUSA | |||
| 11/13/2005 | Southern Miss | 24 | @ | Houston | 27 | CUSA | |||
| 11/19/2005 | SMU | 29 | @ | Houston | 24 | CUSA | |||
| 11/26/2005 | Rice | 18 | @ | Houston | 35 | CUSA | |||
| 12/23/2005 | Kansas | 42 | vs | Houston | 13 | Fort Worth |