| 9/4/2005 | #11 West Virginia | 15 | @ | Syracuse | 7 | BigE | |||
| 9/10/2005 | Buffalo | 0 | @ | Syracuse | 31 | ||||
| 9/17/2005 | Virginia | 27 | @ | Syracuse | 24 | ||||
| 10/1/2005 | Syracuse | 13 | @ | #22 Florida St | 38 | ||||
| 10/7/2005 | Syracuse | 7 | @ | Connecticut | 26 | BigE | |||
| 10/15/2005 | Rutgers | 31 | @ | Syracuse | 9 | BigE | |||
| 10/22/2005 | Syracuse | 17 | @ | Pittsburgh | 34 | BigE | |||
| 10/29/2005 | Cincinnati | 22 | @ | Syracuse | 16 | BigE | |||
| 11/12/2005 | South Florida | 27 | @ | Syracuse | 0 | BigE | |||
| 11/19/2005 | Syracuse | 10 | @ | #5 Notre Dame | 34 | ||||
| 11/26/2005 | Syracuse | 17 | @ | #15 Louisville | 41 | BigE |