| 9/3/2022 | La Verne (2-8) | 0 | at | San Diego | 58 | SCIAC (D3) | ||
| 9/10/2022 | San Diego | 27 | at | Cal Poly (2-9) | 28 | at BSky | ||
| 9/17/2022 | San Diego | 13 | at | UC Davis (6-5) | 43 | at BSky | ||
| 9/24/2022 | San Diego | 21 | at | Valparaiso (5-7,4-4) | 28 | |||
| 10/1/2022 | Stetson (4-6,2-5) | at | San Diego | CCD | ||||
| 10/8/2022 | San Diego | 22 | at | Drake (3-8,3-5) | 10 | |||
| 10/15/2022 | Presbyterian (1-10,0-8) | 3 | at | San Diego | 28 | |||
| 10/29/2022 | San Diego | 42 | at | St Thomas (10-1,8-0) | 49 | |||
| 11/5/2022 | Butler (7-4,5-3) | 26 | at | San Diego | 23 | |||
| 11/12/2022 | Davidson (8-4,6-2) | 14 | at | San Diego | 31 | |||
| 11/19/2022 | San Diego | 14 | at | Morehead State (2-9,1-7) | 9 |
| vs San Diego | vs Other Opponents | San Diego compared to OOs | |
| Record: | 5-5 | 45-66 | |
| Points Scored: | 21.00 | 25.09 | 4.09 |
| Points Allowed: | 27.90 | 30.45 | -2.55 |
| Margin: | -6.90 | -5.36 | 1.54 |
| Total Points: | 48.90 | 55.54 | -6.64 |