| 8/25/2022 | Reinhardt | 34 | at | Faulkner | 27 | |||
| Georgetown KY | 42 | at | Kentucky Christian | 13 | ||||
| 8/27/2022 | Arkansas Baptist | 7 | at | Bethel TN | 77 | None (Unk?) | ||
| Point | 7 | at | Cumberland TN | 34 | ||||
| Union KY | 6 | at | Cumberlands KY | 30 | ||||
| St Andrews | 6 | at | Lindsey Wilson | 57 | ||||
| Bluefield | 42 | at | Thomas More | 35 | ||||
| 9/3/2022 | St Andrews | 14 | at | Campbellsville | 60 | |||
| Webber International | 24 | at | Cumberland TN | 25 | Sun | |||
| Bluefield | 7 | at | Georgetown KY | 52 | ||||
| Thomas More | 31 | at | Kentucky Christian | 28 | ||||
| Faulkner | 14 | at | Point | 10 | ||||
| Bethel TN | 16 | at | Reinhardt | 8 | ||||
| Lindsey Wilson | 50 | at | Union KY | 3 | ||||
| 9/10/2022 | Point | 3 | at | Bethel TN | 28 | |||
| Emory & Henry | 41 | at | Bluefield | 33 | SAC (D2) | |||
| Thomas More | 14 | at | Duquesne | 34 | @ NE (1AA) | |||
| Kentucky Christian | 33 | at | Pikeville | 54 | ||||
| Cumberland TN | at | Reinhardt | PPD | |||||
| Cumberlands KY | 44 | at | St Andrews | 6 | ||||
| Campbellsville | 42 | at | Union KY | 14 | ||||
| 9/17/2022 | Union KY | 10 | at | Bluefield | 29 | |||
| Thomas More | 44 | at | Campbellsville | 36 | ||||
| Lindsey Wilson | 37 | at | Cumberlands KY | 10 | ||||
| St Andrews | 6 | at | Davidson | 56 | @ Pio (1AA) | |||
| Faulkner | 13 | at | Georgetown KY | 23 | ||||
| Kentucky Christian | 14 | at | Morehead State | 49 | @ Pio (1AA) | |||
| Cumberland TN | 37 | at | Pikeville | 47 | ||||
| Reinhardt | 24 | at | Point | 14 | ||||
| 9/24/2022 | Pikeville | 16 | at | Bethel TN | 45 | |||
| Point | 14 | at | Birmingham-Southern | 34 | @ SAA (D3) | |||
| Georgetown KY | 24 | at | Cumberland TN | 0 | ||||
| Cumberlands KY | 20 | at | Faulkner | 23 | OT | |||
| Bluefield | 31 | at | Kentucky Christian | 19 | ||||
| Campbellsville | 12 | at | Lindsey Wilson | 21 | ||||
| Reinhardt | 35 | at | St Andrews | 9 | ||||
| 10/1/2022 | Pikeville | 26 | at | Bluefield | 50 | |||
| Faulkner | 49 | at | Campbellsville | 17 | ||||
| Cumberland TN | 6 | at | Cumberlands KY | 10 | ||||
| Bethel TN | 24 | at | Georgetown KY | 14 | ||||
| St Andrews | 6 | at | Point | 48 | ||||
| Lindsey Wilson | 12 | at | Thomas More | 3 | ||||
| Kentucky Christian | 42 | at | Union KY | 0 | ||||
| 10/8/2022 | Cumberlands KY | 13 | at | Bethel TN | 43 | |||
| Point | 14 | at | Bluefield | 20 | ||||
| Campbellsville | 22 | at | Cumberland TN | 65 | ||||
| Thomas More | 24 | at | Faulkner | 7 | ||||
| Georgetown KY | 40 | at | Pikeville | 20 | ||||
| Kentucky Christian | 21 | at | Reinhardt | 47 | ||||
| Union KY | 26 | at | St Andrews | 27 | ||||
| 10/15/2022 | Reinhardt | 45 | at | Bluefield | 21 | |||
| Bethel TN | 39 | at | Campbellsville | 31 | ||||
| Pikeville | 24 | at | Cumberlands KY | 17 | ||||
| Faulkner | 7 | at | Lindsey Wilson | 37 | ||||
| Cumberland TN | 16 | at | Thomas More | 24 | ||||
| 10/22/2022 | Thomas More | 7 | at | Bethel TN | 57 | |||
| Lindsey Wilson | 27 | at | Cumberland TN | 3 | ||||
| Cumberlands KY | 24 | at | Georgetown KY | 23 | ||||
| Faulkner | 0 | at | Incarnate Word | 70 | @ SLC (1AA) | |||
| St Andrews | 28 | at | Kentucky Christian | 51 | ||||
| Campbellsville | 41 | at | Pikeville | 66 | ||||
| Union KY | 13 | at | Point | 16 | ||||
| 10/29/2022 | Georgetown KY | 65 | at | Campbellsville | 13 | |||
| Cumberland TN | 30 | at | Faulkner | 44 | ||||
| Bethel TN | 21 | at | Lindsey Wilson | 16 | ||||
| Kentucky Christian | 40 | at | Point | 43 | ||||
| St Andrews | 14 | at | Reinhardt | 43 | ||||
| Pikeville | 28 | at | Thomas More | 24 | ||||
| Bluefield | 54 | at | Union KY | 26 | ||||
| 11/5/2022 | Faulkner | 6 | at | Bethel TN | 59 | |||
| Campbellsville | 21 | at | Cumberlands KY | 35 | ||||
| Thomas More | 0 | at | Georgetown KY | 35 | ||||
| Union KY | 12 | at | Kentucky Christian | 33 | ||||
| Lindsey Wilson | 39 | at | Pikeville | 9 | ||||
| Point | 21 | at | Reinhardt | 48 | ||||
| Bluefield | 50 | at | St Andrews | 12 | ||||
| 11/12/2022 | Kentucky Christian | 8 | at | Bluefield | 42 | |||
| Bethel TN | 27 | at | Cumberland TN | 17 | ||||
| Pikeville | 36 | at | Faulkner | 22 | ||||
| Georgetown KY | 17 | at | Lindsey Wilson | 23 | ||||
| Point | 27 | at | St Andrews | 16 | ||||
| Cumberlands KY | 10 | at | Thomas More | 43 | ||||
| Reinhardt | 40 | at | Union KY | 0 | ||||
| 11/19/2022 | Keiser | 27 | at | Bethel TN | 17 | NAIA Championship Round 1 | Sun | |
| Reinhardt | 22 | at | Lindsey Wilson | 23 | NAIA Championship Round 1 | |||
| 11/26/2022 | Lindsey Wilson | 7 | at | Grand View | 10 | NAIA Quarterfinal | @ HAAC |