| 8/27/2022 | Tabor | 17 | at | Iowa Wesleyan | 13 | | | @ NSAA |
| St Mary KS | 10 | at | Midland U. | 64 | | | @ GPAC |
| Friends | 31 | at | Panhandle State | 14 | | | @ Soon |
| 9/3/2022 | McPherson | 13 | at | Bethel KS | 14 | | | |
| Friends | 0 | at | Kansas Wesleyan | 70 | | | |
| Southwestern | 29 | at | Ottawa | 6 | | | |
| Sterling | 11 | at | St Mary KS | 37 | | | |
| Avila | 41 | at | Tabor | 7 | | | |
| 9/10/2022 | Ottawa | 9 | at | Avila | 39 | | | |
| Bethel KS | 28 | at | Friends | 16 | | | |
| Tabor | 17 | at | McPherson | 16 | | | |
| Bethany KS | 0 | at | Southwestern | 65 | | | |
| Kansas Wesleyan | 49 | at | Sterling | 0 | | | |
| 9/17/2022 | Avila | 21 | at | Bethany KS | 0 | | | |
| Bethel KS | | at | Kansas Wesleyan | | | | |
| McPherson | 27 | at | Ottawa | 18 | | | |
| Southwestern | 32 | at | St Mary KS | 14 | | | |
| Friends | 16 | at | Tabor | 35 | | | |
| 9/18/2022 | Bethel KS | 30 | at | Kansas Wesleyan | 24 | | | |
| 9/24/2022 | Ottawa | 21 | at | Bethel KS | 50 | | | |
| St Mary KS | 20 | at | Friends | 38 | | | |
| Bethany KS | 6 | at | Kansas Wesleyan | 49 | | | |
| Avila | 21 | at | Southwestern | 24 | | | |
| Tabor | 21 | at | Sterling | 20 | | | |
| 10/1/2022 | Sterling | 14 | at | Avila | 44 | | | |
| Bethel KS | 42 | at | Bethany KS | 7 | | | |
| McPherson | 22 | at | Southwestern | 23 | | | |
| Kansas Wesleyan | 39 | at | St Mary KS | 13 | | | |
| Ottawa | 19 | at | Tabor | 24 | | | |
| 10/8/2022 | Southwestern | 23 | at | Bethel KS | 31 | | | |
| Avila | 18 | at | Kansas Wesleyan | 14 | | | |
| Friends | 22 | at | McPherson | 31 | | | |
| St Mary KS | 33 | at | Ottawa | 23 | | | |
| Bethany KS | 34 | at | Sterling | 40 | 2OT | | |
| 10/15/2022 | Bethel KS | 14 | at | Avila | 28 | | | |
| Sterling | 7 | at | Friends | 42 | | | |
| Kansas Wesleyan | 14 | at | McPherson | 12 | | | |
| Tabor | 6 | at | Southwestern | 49 | | | |
| Bethany KS | 0 | at | St Mary KS | 41 | | | |
| 10/22/2022 | St Mary KS | 21 | at | Avila | 34 | | | |
| McPherson | 53 | at | Bethany KS | 6 | | | |
| Sterling | 7 | at | Bethel KS | 51 | | | |
| Ottawa | 28 | at | Friends | 13 | | | |
| Tabor | 0 | at | Kansas Wesleyan | 62 | | | |
| 10/29/2022 | Avila | 36 | at | Arkansas Baptist | 6 | | | @ None (Unk?) |
| Friends | 55 | at | Bethany KS | 6 | | | |
| St Mary KS | 10 | at | McPherson | 21 | | | |
| Kansas Wesleyan | 30 | at | Ottawa | 13 | | | |
| Southwestern | 31 | at | Sterling | 14 | | | |
| Bethel KS | 31 | at | Tabor | 14 | | | |
| 11/5/2022 | St Mary KS | 21 | at | Bethel KS | 51 | | | |
| Southwestern | 28 | at | Friends | 0 | | | |
| Arkansas Baptist | 10 | at | Kansas Wesleyan | 67 | | | None (Unk?) |
| Avila | 43 | at | McPherson | 23 | | | |
| Sterling | 28 | at | Ottawa | 13 | | | |
| Bethany KS | 0 | at | Tabor | 35 | | | |
| 11/12/2022 | Friends | 26 | at | Avila | 42 | | | |
| Ottawa | 45 | at | Bethany KS | 2 | | | |
| Kansas Wesleyan | 20 | at | Southwestern | 26 | | | |
| Tabor | 16 | at | St Mary KS | 21 | | | |
| McPherson | 47 | at | Sterling | 10 | | | |
| 11/19/2022 | Southwestern | 7 | at | Benedictine KS | 35 | | NAIA Championship Round 1 | @ HAAC |
| Avila | 7 | at | Indiana Wesleyan | 14 | | NAIA Championship Round 1 | @ MSFA |