| 9/4/2021 | Lake Forest | 27 | at | Wisconsin Lutheran (3-7) | 10 | at NAC | ||
| 9/11/2021 | Lawrence (2-7,1-7) | 26 | at | Lake Forest | 52 | |||
| 9/18/2021 | Lake Forest | 41 | at | Knox (3-6,3-6) | 10 | |||
| 10/2/2021 | Cornell IA (4-6,4-5) | 0 | at | Lake Forest | 17 | |||
| 10/9/2021 | Lake Forest | 48 | at | Illinois College (5-5,5-4) | 13 | |||
| 10/16/2021 | Lake Forest | 42 | at | Ripon (6-3,5-3) | 7 | |||
| 10/23/2021 | Grinnell (2-8,2-7) | 0 | at | Lake Forest | 79 | |||
| 10/30/2021 | Lake Forest | 24 | at | Monmouth IL (8-2,8-1) | 10 | |||
| 11/6/2021 | Beloit (0-10,0-9) | 3 | at | Lake Forest | 84 | |||
| 11/13/2021 | Chicago (8-2,7-2) | 6 | at | Lake Forest | 28 | |||
| 11/20/2021 | Lake Forest | 14 | at | St John's MN (11-1) | 41 | at MIA |
| vs Lake Forest | vs Other Opponents | Lake Forest compared to OOs | |
| Record: | 1-10 | 51-47 | |
| Points Scored: | 11.45 | 30.62 | 19.17 |
| Points Allowed: | 41.45 | 29.15 | 12.30 |
| Margin: | -30.00 | 1.47 | 31.47 |
| Total Points: | 52.90 | 59.77 | -6.87 |