| 9/4/2021 | Grinnell | 13 | at | Rockford (2-8) | 48 | at NAC | ||
| 9/11/2021 | Grinnell | 7 | at | Monmouth IL (8-2,8-1) | 42 | |||
| 9/18/2021 | Lawrence (2-7,1-7) | 28 | at | Grinnell | 35 | OT | ||
| 10/2/2021 | Grinnell | 40 | at | Beloit (0-10,0-9) | 13 | |||
| 10/9/2021 | Ripon (6-3,5-3) | 52 | at | Grinnell | 8 | |||
| 10/16/2021 | Knox (3-6,3-6) | 49 | at | Grinnell | 28 | |||
| 10/23/2021 | Grinnell | 0 | at | Lake Forest (10-1,9-0) | 79 | |||
| 10/30/2021 | Chicago (8-2,7-2) | 78 | at | Grinnell | 3 | |||
| 11/6/2021 | Grinnell | 24 | at | Illinois College (5-5,5-4) | 55 | |||
| 11/13/2021 | Cornell IA (4-6,4-5) | 34 | at | Grinnell | 14 |
| vs Grinnell | vs Other Opponents | Grinnell compared to OOs | |
| Record: | 8-2 | 40-48 | |
| Points Scored: | 47.80 | 27.26 | -20.54 |
| Points Allowed: | 17.20 | 30.13 | -12.93 |
| Margin: | 30.60 | -2.87 | -33.47 |
| Total Points: | 65.00 | 57.39 | 7.61 |