| 9/4/2021 | UNC Pembroke | at | Winston-Salem State (3-6) | Canceled COVID | at CIAA | |||
| 9/11/2021 | UNC Pembroke | 28 | at | Findlay (8-4) | 34 | OT | at GMAC | |
| 9/18/2021 | Glenville State (3-7,3-7) | 22 | at | UNC Pembroke | 36 | |||
| 9/25/2021 | Fairmont State (5-6,5-5) | 30 | at | UNC Pembroke | 27 | |||
| 10/2/2021 | UNC Pembroke | 21 | at | Frostburg State (10-1,9-1) | 51 | |||
| 10/9/2021 | Wheeling (5-6,5-5) | 28 | at | UNC Pembroke | 34 | |||
| 10/16/2021 | UNC Pembroke | 14 | at | West Virginia State (6-5,6-4) | 13 | |||
| 10/23/2021 | Charleston WV (8-2,8-2) | 14 | at | UNC Pembroke | 21 | |||
| 10/30/2021 | UNC Pembroke | 27 | at | West Liberty (4-7,4-6) | 17 | |||
| 11/6/2021 | Notre Dame OH (11-2,9-1) | 45 | at | UNC Pembroke | 7 | |||
| 11/13/2021 | UNC Pembroke | 25 | at | Concord (4-6,4-6) | 28 |
| vs UNC Pembroke | vs Other Opponents | UNC Pembroke compared to OOs | |
| Record: | 5-5 | 62-47 | |
| Points Scored: | 28.20 | 27.48 | -0.72 |
| Points Allowed: | 24.00 | 22.50 | 1.50 |
| Margin: | 4.20 | 4.98 | 0.78 |
| Total Points: | 52.20 | 49.98 | 2.22 |