| 9/4/2021 | Indiana | 6 | at | Iowa (10-4,7-3) | 34 | |||
| 9/11/2021 | Idaho (4-7) | 14 | at | Indiana | 56 | BSky (1AA) | ||
| 9/18/2021 | Cincinnati (13-1) | 38 | at | Indiana | 24 | AAC | ||
| 9/25/2021 | Indiana | 33 | at | Western Kentucky (9-5) | 31 | at CUSA | ||
| 10/2/2021 | Indiana | 0 | at | Penn State (7-6,4-5) | 24 | |||
| 10/16/2021 | Michigan State (11-2,7-2) | 20 | at | Indiana | 15 | |||
| 10/23/2021 | Ohio State (11-2,8-1) | 54 | at | Indiana | 7 | |||
| 10/30/2021 | Indiana | 35 | at | Maryland (7-6,3-6) | 38 | |||
| 11/6/2021 | Indiana | 7 | at | Michigan (12-2,9-1) | 29 | |||
| 11/13/2021 | Rutgers (5-8,2-7) | 38 | at | Indiana | 3 | |||
| 11/20/2021 | Minnesota (9-4,6-3) | 35 | at | Indiana | 14 | |||
| 11/27/2021 | Indiana | 7 | at | Purdue (9-4,6-3) | 44 |
| vs Indiana | vs Other Opponents | Indiana compared to OOs | |
| Record: | 10-2 | 97-49 | |
| Points Scored: | 33.25 | 30.98 | -2.27 |
| Points Allowed: | 17.25 | 23.27 | -6.02 |
| Margin: | 16.00 | 7.71 | -8.29 |
| Total Points: | 50.50 | 54.25 | -3.75 |