D2
11 Jan 2022 16:14:08
| 9/2/2021 | West Virginia Wesleyan | 3 | at | Drake | 45 | | | @ Pio (1AA) |
| California PA | 23 | at | Fairmont State | 14 | | | PSAC |
| Frostburg State | 20 | at | Kentucky Wesleyan | 13 | | | @ GMAC |
| Wheeling | 14 | at | Seton Hill | 16 | | | @ PSAC |
| Walsh | 27 | at | West Liberty | 6 | | | GMAC |
| 9/4/2021 | Alderson-Broaddus | 3 | at | Mercyhurst | 18 | | | @ PSAC |
| Ashland | 35 | at | Notre Dame OH | 42 | OT | | GMAC |
| West Virginia State | 17 | at | Shippensburg | 25 | | | @ PSAC |
| UNC Pembroke | | at | Winston-Salem State | | | Canceled COVID | @ CIAA |
| 9/9/2021 | Fairmont State | 6 | at | Charleston WV | 27 | | | |
| Concord | 10 | at | Glenville State | 17 | | | |
| Notre Dame OH | 31 | at | Wheeling | 15 | | | |
| 9/11/2021 | West Liberty | 24 | at | Alderson-Broaddus | 0 | | | |
| UNC Pembroke | 28 | at | Findlay | 34 | OT | | @ GMAC |
| Frostburg State | 34 | at | West Virginia State | 21 | | | |
| 9/16/2021 | Charleston WV | 24 | at | Frostburg State | 30 | 2OT | | |
| 9/18/2021 | West Virginia Wesleyan | 25 | at | Concord | 28 | | | |
| West Virginia State | 30 | at | Fairmont State | 23 | | | |
| Glenville State | 22 | at | UNC Pembroke | 36 | | | |
| Notre Dame OH | 51 | at | West Liberty | 10 | | | |
| Alderson-Broaddus | 6 | at | Wheeling | 28 | | | |
| 9/25/2021 | Charleston WV | 69 | at | Alderson-Broaddus | 7 | | | |
| Frostburg State | 42 | at | Concord | 23 | | | |
| Wheeling | 27 | at | Glenville State | 10 | | | |
| West Virginia State | 14 | at | Notre Dame OH | 38 | | | |
| Fairmont State | 30 | at | UNC Pembroke | 27 | | | |
| West Liberty | 31 | at | West Virginia Wesleyan | 0 | | | |
| 10/2/2021 | Notre Dame OH | 28 | at | Charleston WV | 38 | | | |
| Concord | 27 | at | Fairmont State | 31 | | | |
| UNC Pembroke | 21 | at | Frostburg State | 51 | | | |
| Glenville State | 19 | at | West Liberty | 20 | | | |
| Alderson-Broaddus | 13 | at | West Virginia State | 45 | | | |
| West Virginia Wesleyan | 0 | at | Wheeling | 38 | | | |
| 10/9/2021 | West Liberty | 16 | at | Concord | 20 | | | |
| Alderson-Broaddus | 10 | at | Fairmont State | 44 | | | |
| Charleston WV | 20 | at | Glenville State | 9 | | | |
| Frostburg State | 21 | at | Notre Dame OH | 23 | | | |
| Wheeling | 28 | at | UNC Pembroke | 34 | | | |
| West Virginia State | 38 | at | West Virginia Wesleyan | 3 | | | |
| 10/16/2021 | Glenville State | 35 | at | Alderson-Broaddus | 21 | | | |
| Concord | 3 | at | Charleston WV | 48 | | | |
| Wheeling | 17 | at | Frostburg State | 41 | | | |
| West Virginia Wesleyan | 14 | at | Notre Dame OH | 52 | | | |
| Fairmont State | 31 | at | West Liberty | 52 | | | |
| UNC Pembroke | 14 | at | West Virginia State | 13 | | | |
| 10/23/2021 | West Virginia State | 34 | at | Concord | 32 | | | |
| Frostburg State | 49 | at | Fairmont State | 14 | | | |
| Notre Dame OH | 34 | at | Glenville State | 14 | | | |
| Charleston WV | 14 | at | UNC Pembroke | 21 | | | |
| West Liberty | 20 | at | Wheeling | 26 | OT | | |
| Alderson-Broaddus | 49 | at | West Virginia Wesleyan | 20 | | | |
| 10/28/2021 | West Virginia Wesleyan | 6 | at | Charleston WV | 45 | | | |
| 10/30/2021 | Frostburg State | 45 | at | Alderson-Broaddus | 7 | | | |
| Fairmont State | 0 | at | Notre Dame OH | 45 | | | |
| UNC Pembroke | 27 | at | West Liberty | 17 | | | |
| Glenville State | 27 | at | West Virginia State | 38 | | | |
| Concord | 14 | at | Wheeling | 15 | | | |
| 11/6/2021 | Concord | 23 | at | Alderson-Broaddus | 10 | | | |
| Wheeling | 20 | at | Charleston WV | 38 | | | |
| West Virginia Wesleyan | 14 | at | Frostburg State | 55 | | | |
| Fairmont State | 24 | at | Glenville State | 14 | | | |
| Notre Dame OH | 45 | at | UNC Pembroke | 7 | | | |
| West Virginia State | 33 | at | West Liberty | 28 | | | |
| 11/11/2021 | West Liberty | 3 | at | Frostburg State | 56 | | | |
| 11/12/2021 | Wheeling | 14 | at | Fairmont State | 29 | | | |
| 11/13/2021 | UNC Pembroke | 25 | at | Concord | 28 | | | |
| Alderson-Broaddus | 7 | at | Notre Dame OH | 72 | | | |
| Charleston WV | 38 | at | West Virginia State | 13 | | | |
| Glenville State | 43 | at | West Virginia Wesleyan | 13 | | | |
| 11/20/2021 | Slippery Rock | 25 | at | Notre Dame OH | 33 | | | PSAC |
| 11/27/2021 | Notre Dame OH | 34 | at | Shepherd | 38 | | | @ PSAC |