| 10/24/2020 | Rutgers (3-6,3-6) | 38 | at | Michigan State | 27 | |||
| 10/31/2020 | Michigan State | 27 | at | Michigan (2-4,2-4) | 24 | |||
| 11/7/2020 | Michigan State | 7 | at | Iowa (6-2,6-2) | 49 | |||
| 11/14/2020 | Indiana (6-2,6-1) | 24 | at | Michigan State | 0 | |||
| 11/21/2020 | Michigan State | at | Maryland (2-3,2-3) | CCD | ||||
| 11/28/2020 | Northwestern (7-2,6-2) | 20 | at | Michigan State | 29 | |||
| 12/5/2020 | Ohio State (7-1,6-0) | 52 | at | Michigan State | 12 | |||
| 12/12/2020 | Michigan State | 24 | at | Penn State (4-5,4-5) | 39 | |||
| 12/19/2020 | Michigan State | at | Maryland (2-3,2-3) | CCD |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 5-2 | 34-26 | |
| Points Scored: | 35.14 | 28.38 | -6.76 |
| Points Allowed: | 18.00 | 26.30 | -8.30 |
| Margin: | 17.14 | 2.08 | -15.06 |
| Total Points: | 53.14 | 54.68 | -1.54 |