| 10/24/2020 | Nebraska (3-5,3-5) | 17 | at | Ohio State | 52 | |||
| 10/31/2020 | Ohio State | 38 | at | Penn State (4-5,4-5) | 25 | |||
| 11/7/2020 | Rutgers (3-6,3-6) | 27 | at | Ohio State | 49 | |||
| 11/14/2020 | Ohio State | at | Maryland (2-3,2-3) | CCD | ||||
| 11/21/2020 | Indiana (6-2,6-1) | 35 | at | Ohio State | 42 | |||
| 11/28/2020 | Ohio State | at | Illinois (2-6,2-6) | CCD | ||||
| 12/5/2020 | Ohio State | 52 | at | Michigan State (2-5,2-5) | 12 | |||
| 12/12/2020 | Michigan (2-4,2-4) | at | Ohio State | CCD | ||||
| 12/19/2020 | Northwestern (7-2,6-2) | 10 | vs | Ohio State | 22 | B10 Championship | ||
| 1/1/2021 | Ohio State | 49 | vs | Clemson (10-2) | 28 | Sugar Bowl | vs ACC | |
| 1/11/2021 | Ohio State | 24 | vs | Alabama (13-0) | 52 | FBS Championship | vs SEC |
| vs Ohio State | vs Other Opponents | Ohio State compared to OOs | |
| Record: | 1-7 | 53-33 | |
| Points Scored: | 25.75 | 31.01 | 5.26 |
| Points Allowed: | 41.00 | 24.84 | 16.16 |
| Margin: | -15.25 | 6.17 | 21.42 |
| Total Points: | 66.75 | 55.85 | 10.90 |