| 10/24/2020 | Maryland (2-3,2-3) | 3 | at | Northwestern | 43 | |||
| 10/31/2020 | Northwestern | 21 | at | Iowa (6-2,6-2) | 20 | |||
| 11/7/2020 | Nebraska (3-5,3-5) | 13 | at | Northwestern | 21 | |||
| 11/14/2020 | Northwestern | 27 | at | Purdue (2-4,2-4) | 20 | |||
| 11/21/2020 | Wisconsin (4-3,3-3) | 7 | at | Northwestern | 17 | |||
| 11/28/2020 | Northwestern | 20 | at | Michigan State (2-5,2-5) | 29 | |||
| 12/5/2020 | Northwestern | at | Minnesota (3-4,3-4) | CCD | ||||
| 12/12/2020 | Illinois (2-6,2-6) | 10 | at | Northwestern | 28 | |||
| 12/19/2020 | Northwestern | 10 | vs | Ohio State (7-1,6-0) | 22 | B10 Championship | ||
| 1/1/2021 | Auburn (6-5) | 19 | vs | Northwestern | 35 | Citrus Bowl | SEC |
| vs Northwestern | vs Other Opponents | Northwestern compared to OOs | |
| Record: | 2-7 | 35-31 | |
| Points Scored: | 15.89 | 27.80 | 11.91 |
| Points Allowed: | 24.67 | 27.52 | -2.85 |
| Margin: | -8.78 | 0.28 | 9.06 |
| Total Points: | 40.56 | 55.32 | -14.76 |