| 9/12/2020 | Western Kentucky | 21 | at | Louisville (4-7) | 35 | at ACC | ||
| 9/19/2020 | Liberty (10-1) | 30 | at | Western Kentucky | 24 | Ind | ||
| 10/3/2020 | Western Kentucky | 20 | at | Middle Tenn State (3-5,2-3) | 17 | |||
| 10/10/2020 | Marshall (6-3,3-2) | 38 | at | Western Kentucky | 14 | |||
| 10/17/2020 | Western Kentucky | 14 | at | UAB (6-3,4-1) | 37 | |||
| 10/24/2020 | Chattanooga (0-1) | 10 | at | Western Kentucky | 13 | SoCon (1AA) | ||
| 10/31/2020 | Western Kentucky | 10 | at | BYU (11-1) | 41 | at Ind | ||
| 11/7/2020 | Western Kentucky | 6 | at | Florida Atlantic (5-4,4-2) | 10 | |||
| 11/14/2020 | Southern Miss (3-7,2-4) | 7 | at | Western Kentucky | 10 | |||
| 11/21/2020 | Florida Intl (0-6,0-3) | 21 | at | Western Kentucky | 38 | |||
| 12/6/2020 | Western Kentucky | 37 | at | UNC-Charlotte (2-4,2-2) | 19 | |||
| 12/26/2020 | Western Kentucky | 21 | vs | Georgia State (6-4) | 39 | Lending Tree Bowl | vs SBC |
| vs Western Kentucky | vs Other Opponents | Western Kentucky compared to OOs | |
| Record: | 7-5 | 49-41 | |
| Points Scored: | 25.33 | 30.04 | 4.71 |
| Points Allowed: | 19.00 | 24.97 | -5.97 |
| Margin: | 6.33 | 5.07 | -1.26 |
| Total Points: | 44.33 | 55.01 | -10.68 |