| 9/12/2020 | UL Lafayette (10-1) | 31 | at | Iowa State | 14 | SBC | ||
| 9/26/2020 | Iowa State | 37 | at | TCU (6-4,5-4) | 34 | |||
| 10/3/2020 | Oklahoma (9-2,7-2) | 30 | at | Iowa State | 37 | |||
| 10/10/2020 | Texas Tech (4-6,3-6) | 15 | at | Iowa State | 31 | |||
| 10/24/2020 | Iowa State | 21 | at | Oklahoma State (8-3,6-3) | 24 | |||
| 10/31/2020 | Iowa State | 52 | at | Kansas (0-9,0-8) | 22 | |||
| 11/7/2020 | Baylor (2-7,2-7) | 31 | at | Iowa State | 38 | |||
| 11/21/2020 | Kansas State (4-6,4-5) | 0 | at | Iowa State | 45 | |||
| 11/27/2020 | Iowa State | 23 | at | Texas (7-3,5-3) | 20 | |||
| 12/5/2020 | West Virginia (6-4,4-4) | 6 | at | Iowa State | 42 | |||
| 12/19/2020 | Oklahoma (9-2,7-2) | 27 | vs | Iowa State | 21 | B12 Championship | ||
| 1/2/2021 | Oregon (4-3) | 17 | vs | Iowa State | 34 | Fiesta Bowl | P12 |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 3-9 | 65-40 | |
| Points Scored: | 21.42 | 33.51 | 12.09 |
| Points Allowed: | 32.92 | 27.42 | 5.50 |
| Margin: | -11.50 | 6.09 | 17.59 |
| Total Points: | 54.34 | 60.93 | -6.59 |