| 9/19/2020 | Tulsa (6-3) | 7 | at | Oklahoma State | 16 | AAC | ||
| 9/26/2020 | West Virginia (6-4,4-4) | 13 | at | Oklahoma State | 27 | |||
| 10/3/2020 | Oklahoma State | 47 | at | Kansas (0-9,0-8) | 7 | |||
| 10/17/2020 | Oklahoma State | at | Baylor (2-7,2-7) | PPD | ||||
| 10/24/2020 | Iowa State (9-3,8-2) | 21 | at | Oklahoma State | 24 | |||
| 10/31/2020 | Texas (7-3,5-3) | 41 | at | Oklahoma State | 34 | OT | ||
| 11/7/2020 | Oklahoma State | 20 | at | Kansas State (4-6,4-5) | 18 | |||
| 11/21/2020 | Oklahoma State | 13 | at | Oklahoma (9-2,7-2) | 41 | |||
| 11/28/2020 | Texas Tech (4-6,3-6) | 44 | at | Oklahoma State | 50 | |||
| 12/5/2020 | Oklahoma State | 22 | at | TCU (6-4,5-4) | 29 | |||
| 12/12/2020 | Oklahoma State | 42 | at | Baylor (2-7,2-7) | 3 | |||
| 12/29/2020 | Oklahoma State | 37 | vs | Miami-Florida (8-3) | 34 | Cheez-It Bowl | vs ACC |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 3-8 | 60-48 | |
| Points Scored: | 23.45 | 30.99 | 7.54 |
| Points Allowed: | 30.18 | 27.93 | 2.25 |
| Margin: | -6.73 | 3.06 | 9.79 |
| Total Points: | 53.63 | 58.92 | -5.29 |