| 9/12/2020 | Coastal Carolina | 38 | at | Kansas (0-9) | 23 | at B12 | ||
| 9/18/2020 | Campbell (0-4) | 21 | at | Coastal Carolina | 43 | BigS (1AA) | ||
| 10/3/2020 | Arkansas State (4-7,2-6) | 23 | at | Coastal Carolina | 52 | |||
| 10/14/2020 | Coastal Carolina | 30 | at | UL Lafayette (10-1,7-1) | 27 | |||
| 10/24/2020 | Georgia Southern (8-5,4-4) | 14 | at | Coastal Carolina | 28 | |||
| 10/31/2020 | Coastal Carolina | 51 | at | Georgia State (6-4,4-4) | 0 | |||
| 11/7/2020 | South Alabama (4-7,3-5) | 6 | at | Coastal Carolina | 23 | |||
| 11/14/2020 | Coastal Carolina | at | Troy (5-6,3-4) | PPD | ||||
| 11/21/2020 | Appalachian State (9-3,6-2) | 23 | at | Coastal Carolina | 34 | |||
| 11/28/2020 | Coastal Carolina | 49 | at | Texas State (2-10,2-6) | 14 | |||
| 12/5/2020 | BYU (11-1) | 17 | at | Coastal Carolina | 22 | Ind | ||
| 12/12/2020 | Coastal Carolina | 42 | at | Troy (5-6,3-4) | 38 | |||
| 12/19/2020 | UL Lafayette (10-1,7-1) | at | Coastal Carolina | CCD SBC Championship | ||||
| 12/26/2020 | Liberty (10-1) | 37 | vs | Coastal Carolina | 34 | OT | Cure Bowl | Ind |
| vs Coastal Carolina | vs Other Opponents | Coastal Carolina compared to OOs | |
| Record: | 1-11 | 83-52 | |
| Points Scored: | 20.25 | 31.64 | 11.39 |
| Points Allowed: | 37.17 | 26.74 | 10.43 |
| Margin: | -16.92 | 4.90 | 21.82 |
| Total Points: | 57.42 | 58.38 | -0.96 |