| 9/2/2019 | Notre Dame | 35 | at | Louisville | 17 | @ ACC | ||
| 9/14/2019 | New Mexico | 14 | at | Notre Dame | 66 | MW | ||
| 9/21/2019 | Notre Dame | 17 | at | Georgia | 23 | @ SEC | ||
| 9/28/2019 | Virginia | 20 | at | Notre Dame | 35 | ACC | ||
| 10/5/2019 | Bowling Green | 0 | at | Notre Dame | 52 | MAC | ||
| 10/12/2019 | Southern California | 27 | at | Notre Dame | 30 | P12 | ||
| 10/26/2019 | Notre Dame | 14 | at | Michigan | 45 | @ B10 | ||
| 11/2/2019 | Virginia Tech | 20 | at | Notre Dame | 21 | ACC | ||
| 11/9/2019 | Notre Dame | 38 | at | Duke | 7 | @ ACC | ||
| 11/16/2019 | Navy | 20 | at | Notre Dame | 52 | AAC | ||
| 11/23/2019 | Boston College | 7 | at | Notre Dame | 40 | ACC | ||
| 11/30/2019 | Notre Dame | 45 | at | Stanford | 24 | @ P12 | ||
| 12/28/2019 | Notre Dame | 33 | vs | Iowa State | 9 | Camping World Bowl - Orlando FL | vs B12 |