| 9/1/2018 | Humboldt State (2-8) | 12 | at | Midwestern State | 55 | GNWAC | ||
| 9/8/2018 | West Florida (6-5) | 17 | at | Midwestern State | 38 | GSC | ||
| 9/15/2018 | Midwestern State | 43 | at | Texas-Permian Basin (2-9,1-7) | 21 | |||
| 9/22/2018 | Angelo State (6-6,4-4) | 36 | at | Midwestern State | 57 | |||
| 9/29/2018 | Midwestern State | 31 | at | Eastern New Mexico (5-6,4-4) | 23 | |||
| 10/6/2018 | Texas A&M-Commerce (10-3,7-2) | at | Midwestern State | CCD | ||||
| 10/7/2018 | Texas A&M-Commerce (10-3,7-2) | 20 | vs | Midwestern State | 19 | Wichita Falls TX/Denton TX | ||
| 10/13/2018 | Midwestern State | 69 | at | Texas A&M-Kingsville (4-7,2-6) | 14 | |||
| 10/27/2018 | Tarleton State (12-1,9-0) | 35 | at | Midwestern State | 34 | OT | ||
| 11/3/2018 | Midwestern State | 48 | at | Western New Mexico (0-10,0-8) | 35 | |||
| 11/10/2018 | West Texas A&M (6-5,4-4) | 23 | at | Midwestern State | 24 | OT |
| vs Midwestern State | vs Other Opponents | Midwestern State compared to OOs | |
| Record: | 2-8 | 60-55 | |
| Points Scored: | 23.60 | 27.83 | 4.23 |
| Points Allowed: | 41.80 | 25.86 | 15.94 |
| Margin: | -18.20 | 1.97 | 20.17 |
| Total Points: | 65.40 | 53.69 | 11.71 |