| 9/1/2018 | Louisville | 14 | vs | Alabama (14-1) | 51 | Orlando FL | vs SEC | |
| 9/8/2018 | Indiana State (7-4) | 7 | at | Louisville | 31 | MVC (1AA) | ||
| 9/15/2018 | Western Kentucky (3-9) | 17 | at | Louisville | 20 | CUSA | ||
| 9/22/2018 | Louisville | 3 | at | Virginia (8-5,4-4) | 27 | |||
| 9/29/2018 | Florida State (5-7,3-5) | 28 | at | Louisville | 24 | |||
| 10/5/2018 | Georgia Tech (7-6,5-3) | 66 | at | Louisville | 31 | |||
| 10/13/2018 | Louisville | 20 | at | Boston College (7-5,4-4) | 38 | |||
| 10/27/2018 | Wake Forest (7-6,3-5) | 56 | at | Louisville | 35 | |||
| 11/3/2018 | Louisville | 16 | at | Clemson (15-0,9-0) | 77 | |||
| 11/9/2018 | Louisville | 23 | at | Syracuse (10-3,6-2) | 54 | |||
| 11/17/2018 | North Carolina State (9-4,5-3) | 52 | at | Louisville | 10 | |||
| 11/24/2018 | Kentucky (10-3) | 56 | at | Louisville | 10 | SEC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 10-2 | 92-51 | |
| Points Scored: | 44.08 | 32.31 | -11.77 |
| Points Allowed: | 19.75 | 24.69 | -4.94 |
| Margin: | 24.33 | 7.62 | -16.71 |
| Total Points: | 63.83 | 57.00 | 6.83 |