| 9/2/2016 | Cal Poly | 27 | at | Nevada (5-7) | 30 | OT | at MW | |
| 9/10/2016 | San Diego (10-2) | 16 | at | Cal Poly | 38 | Pio | ||
| 9/17/2016 | Cal Poly | 38 | at | South Dakota State (9-4) | 31 | at MVC | ||
| 9/24/2016 | Montana (6-5,3-5) | 41 | at | Cal Poly | 42 | |||
| 10/1/2016 | Cal Poly | 24 | at | North Dakota (9-3,8-0) | 31 | |||
| 10/15/2016 | Cal Poly | 55 | at | Portland State (3-8,2-6) | 35 | |||
| 10/22/2016 | UC Davis (3-8,2-6) | 16 | at | Cal Poly | 21 | |||
| 10/29/2016 | Cal Poly | 59 | at | Sacramento State (2-9,2-7) | 47 | |||
| 11/5/2016 | Eastern Washington (12-2,8-0) | 42 | at | Cal Poly | 21 | |||
| 11/12/2016 | Cal Poly | 15 | at | Weber State (7-5,7-2) | 22 | |||
| 11/19/2016 | Northern Colorado (6-5,4-4) | 48 | at | Cal Poly | 55 | |||
| 11/26/2016 | San Diego (10-2) | 35 | at | Cal Poly | 21 | Pio |
| vs Cal Poly | vs Other Opponents | Cal Poly compared to OOs | |
| Record: | 5-7 | 76-52 | |
| Points Scored: | 32.83 | 32.90 | 0.07 |
| Points Allowed: | 34.67 | 28.34 | 6.33 |
| Margin: | -1.84 | 4.56 | 6.40 |
| Total Points: | 67.50 | 61.24 | 6.26 |