| 9/3/2016 | Boise State (10-3) | 45 | at | UL Lafayette | 10 | MW | ||
| 9/10/2016 | McNeese State (6-5) | 22 | at | UL Lafayette | 30 | SLC (1AA) | ||
| 9/17/2016 | South Alabama (6-7,2-6) | 23 | at | UL Lafayette | 28 | |||
| 9/24/2016 | UL Lafayette | 39 | at | Tulane (4-8) | 41 | 4OT | at AAC | |
| 10/1/2016 | UL Lafayette | 31 | at | New Mexico State (3-9,2-6) | 37 | 2OT | ||
| 10/12/2016 | Appalachian State (10-3,7-1) | 24 | at | UL Lafayette | 0 | |||
| 10/22/2016 | UL Lafayette | 27 | at | Texas State (2-10,0-8) | 3 | |||
| 11/5/2016 | Idaho (9-4,6-2) | 23 | at | UL Lafayette | 13 | |||
| 11/10/2016 | UL Lafayette | 33 | at | Georgia Southern (5-7,4-4) | 26 | |||
| 11/19/2016 | UL Lafayette | 21 | at | Georgia (8-5) | 35 | at SEC | ||
| 11/26/2016 | Arkansas State (8-5,7-1) | 19 | at | UL Lafayette | 24 | |||
| 12/3/2016 | UL Lafayette | 30 | at | UL Monroe (4-8,3-5) | 3 | |||
| 12/17/2016 | Southern Miss (7-6) | 28 | vs | UL Lafayette | 21 | New Orleans Bowl | CUSA |
| vs UL Lafayette | vs Other Opponents | UL Lafayette compared to OOs | |
| Record: | 7-6 | 75-74 | |
| Points Scored: | 25.31 | 27.40 | 2.09 |
| Points Allowed: | 23.62 | 29.02 | -5.40 |
| Margin: | 1.69 | -1.62 | -3.31 |
| Total Points: | 48.93 | 56.42 | -7.49 |