| 9/3/2015 | Western Kentucky | 14 | at | Vanderbilt (4-8) | 12 | at SEC | ||
| 9/10/2015 | Louisiana Tech (9-4,6-2) | 38 | at | Western Kentucky | 41 | |||
| 9/19/2015 | Western Kentucky | 35 | at | Indiana (6-7) | 38 | at B10 | ||
| 9/26/2015 | Miami-Ohio (3-9) | 14 | at | Western Kentucky | 56 | MAC | ||
| 10/3/2015 | Western Kentucky | 49 | at | Rice (5-7,3-5) | 10 | |||
| 10/10/2015 | Middle Tenn State (7-6,6-2) | 28 | at | Western Kentucky | 58 | |||
| 10/15/2015 | Western Kentucky | 55 | at | North Texas (1-11,1-7) | 28 | |||
| 10/24/2015 | Western Kentucky | 20 | at | LSU (9-3) | 48 | at SEC | ||
| 10/31/2015 | Western Kentucky | 55 | at | Old Dominion (5-7,3-5) | 30 | |||
| 11/7/2015 | Florida Atlantic (3-9,3-5) | 19 | at | Western Kentucky | 35 | |||
| 11/21/2015 | Western Kentucky | 63 | at | Florida Intl (5-7,3-5) | 7 | |||
| 11/27/2015 | Marshall (10-3,6-2) | 28 | at | Western Kentucky | 49 | |||
| 12/5/2015 | Southern Miss (9-5,7-2) | 28 | at | Western Kentucky | 45 | CUSA Championship | ||
| 12/21/2015 | Western Kentucky | 45 | vs | South Florida (8-5) | 35 | Miami Beach Bowl (Miami FL) | vs AAC |
| vs Western Kentucky | vs Other Opponents | Western Kentucky compared to OOs | |
| Record: | 2-12 | 82-79 | |
| Points Scored: | 25.93 | 28.50 | 2.57 |
| Points Allowed: | 44.29 | 27.48 | 16.81 |
| Margin: | -18.36 | 1.02 | 19.38 |
| Total Points: | 70.22 | 55.98 | 14.24 |