| 9/3/2015 | Western Kentucky (12-2) | 14 | at | Vanderbilt | 12 | CUSA | ||
| 9/12/2015 | Georgia (10-3,5-3) | 31 | at | Vanderbilt | 14 | |||
| 9/19/2015 | Austin Peay (0-11) | 7 | at | Vanderbilt | 47 | OVC (1AA) | ||
| 9/26/2015 | Vanderbilt | 17 | at | Mississippi (10-3,6-2) | 26 | |||
| 10/3/2015 | Vanderbilt | 17 | at | Middle Tenn State (7-6) | 13 | at CUSA | ||
| 10/17/2015 | Vanderbilt | 10 | at | South Carolina (3-9,1-7) | 19 | |||
| 10/24/2015 | Missouri (5-7,1-7) | 3 | at | Vanderbilt | 10 | |||
| 10/31/2015 | Vanderbilt | 0 | at | Houston (13-1) | 34 | at AAC | ||
| 11/7/2015 | Vanderbilt | 7 | at | Florida (10-4,7-2) | 9 | |||
| 11/14/2015 | Kentucky (5-7,2-6) | 17 | at | Vanderbilt | 21 | |||
| 11/21/2015 | Texas A&M (8-5,4-4) | 25 | at | Vanderbilt | 0 | |||
| 11/28/2015 | Vanderbilt | 28 | at | Tennessee (9-4,5-3) | 53 |
| vs Vanderbilt | vs Other Opponents | Vanderbilt compared to OOs | |
| Record: | 8-4 | 84-58 | |
| Points Scored: | 20.92 | 29.91 | 8.99 |
| Points Allowed: | 15.25 | 24.05 | -8.80 |
| Margin: | 5.67 | 5.86 | 0.19 |
| Total Points: | 36.17 | 53.96 | -17.79 |