| 9/5/2015 | Jackson State (3-8) | 14 | at | Middle Tenn State | 70 | SWAC (1AA) | ||
| 9/12/2015 | Middle Tenn State | 10 | at | Alabama (14-1) | 37 | at SEC | ||
| 9/19/2015 | UNC-Charlotte (2-10,0-8) | 14 | at | Middle Tenn State | 73 | |||
| 9/26/2015 | Middle Tenn State | 25 | at | Illinois (5-7) | 27 | at B10 | ||
| 10/3/2015 | Vanderbilt (4-8) | 17 | at | Middle Tenn State | 13 | SEC | ||
| 10/10/2015 | Middle Tenn State | 28 | at | Western Kentucky (12-2,9-0) | 58 | |||
| 10/17/2015 | Florida Intl (5-7,3-5) | 34 | at | Middle Tenn State | 42 | |||
| 10/24/2015 | Middle Tenn State | 16 | at | Louisiana Tech (9-4,6-2) | 45 | |||
| 11/7/2015 | Marshall (10-3,6-2) | 24 | at | Middle Tenn State | 27 | 3OT | ||
| 11/14/2015 | Middle Tenn State | 24 | at | Florida Atlantic (3-9,3-5) | 17 | |||
| 11/21/2015 | North Texas (1-11,1-7) | 7 | at | Middle Tenn State | 41 | |||
| 11/28/2015 | Middle Tenn State | 42 | at | Texas-San Antonio (3-9,3-5) | 7 | |||
| 12/24/2015 | Middle Tenn State | 31 | vs | Western Michigan (8-5) | 45 | Popeyes Bahamas Bowl | vs MAC |
| vs Middle Tenn State | vs Other Opponents | Middle Tenn State compared to OOs | |
| Record: | 6-7 | 73-77 | |
| Points Scored: | 26.62 | 27.37 | 0.75 |
| Points Allowed: | 34.00 | 26.88 | 7.12 |
| Margin: | -7.38 | 0.49 | 7.87 |
| Total Points: | 60.62 | 54.25 | 6.37 |