| 9/5/2015 | Mississippi State (9-4) | 34 | at | Southern Miss | 16 | SEC | ||
| 9/12/2015 | Austin Peay (0-11) | 6 | at | Southern Miss | 52 | OVC (1AA) | ||
| 9/19/2015 | Southern Miss | 56 | at | Texas State (3-9) | 50 | at SBC | ||
| 9/26/2015 | Southern Miss | 28 | at | Nebraska (6-7) | 36 | at B10 | ||
| 10/3/2015 | North Texas (1-11,1-7) | 14 | at | Southern Miss | 49 | |||
| 10/9/2015 | Southern Miss | 10 | at | Marshall (10-3,6-2) | 31 | |||
| 10/17/2015 | Texas-San Antonio (3-9,3-5) | 10 | at | Southern Miss | 32 | |||
| 10/24/2015 | Southern Miss | 44 | at | UNC-Charlotte (2-10,0-8) | 10 | |||
| 10/31/2015 | UTEP (5-7,3-5) | 13 | at | Southern Miss | 34 | |||
| 11/14/2015 | Southern Miss | 65 | at | Rice (5-7,3-5) | 10 | |||
| 11/21/2015 | Old Dominion (5-7,3-5) | 31 | at | Southern Miss | 56 | |||
| 11/28/2015 | Southern Miss | 58 | at | Louisiana Tech (9-4,6-2) | 24 | |||
| 12/5/2015 | Southern Miss | 28 | at | Western Kentucky (12-2,9-0) | 45 | CUSA Championship | ||
| 12/26/2015 | Washington (7-6) | 44 | vs | Southern Miss | 31 | Heart of Dallas Bowl (Dallas TX) | P12 |
| vs Southern Miss | vs Other Opponents | Southern Miss compared to OOs | |
| Record: | 5-9 | 72-88 | |
| Points Scored: | 25.57 | 27.44 | 1.87 |
| Points Allowed: | 39.93 | 29.81 | 10.12 |
| Margin: | -14.36 | -2.37 | 11.99 |
| Total Points: | 65.50 | 57.25 | 8.25 |