| 9/3/2015 | Elon (4-7) | 3 | at | Wake Forest | 41 | CAAF (1AA) | ||
| 9/12/2015 | Wake Forest | 17 | at | Syracuse (4-8,2-6) | 30 | |||
| 9/19/2015 | Wake Forest | 17 | at | Army (2-10) | 14 | at Ind | ||
| 9/26/2015 | Indiana (6-7) | 31 | at | Wake Forest | 24 | B10 | ||
| 10/3/2015 | Florida State (10-3,6-2) | 24 | at | Wake Forest | 16 | |||
| 10/10/2015 | Wake Forest | 3 | at | Boston College (3-9,0-8) | 0 | |||
| 10/17/2015 | Wake Forest | 14 | at | North Carolina (11-3,8-1) | 50 | |||
| 10/24/2015 | North Carolina State (7-6,3-5) | 35 | at | Wake Forest | 17 | |||
| 10/30/2015 | Louisville (8-5,5-3) | 20 | at | Wake Forest | 19 | |||
| 11/14/2015 | Wake Forest | 7 | at | Notre Dame (10-3) | 28 | at ND | ||
| 11/21/2015 | Wake Forest | 13 | at | Clemson (14-1,9-0) | 33 | |||
| 11/28/2015 | Duke (8-5,4-4) | 27 | at | Wake Forest | 21 |
| vs Wake Forest | vs Other Opponents | Wake Forest compared to OOs | |
| Record: | 9-3 | 78-64 | |
| Points Scored: | 24.58 | 30.59 | 6.01 |
| Points Allowed: | 17.42 | 25.56 | -8.14 |
| Margin: | 7.16 | 5.03 | -2.13 |
| Total Points: | 42.00 | 56.15 | -14.15 |