| 9/5/2015 | Texas | 3 | at | Notre Dame | 38 | B12 | ||
| 9/12/2015 | Notre Dame | 34 | at | Virginia | 27 | @ ACC | ||
| 9/19/2015 | Georgia Tech | 22 | at | Notre Dame | 30 | ACC | ||
| 9/26/2015 | Massachusetts | 27 | at | Notre Dame | 62 | MAC | ||
| 10/3/2015 | Notre Dame | 22 | at | Clemson | 24 | @ ACC | ||
| 10/10/2015 | Navy | 24 | at | Notre Dame | 41 | AAC | ||
| 10/17/2015 | Southern California | 31 | at | Notre Dame | 41 | P12 | ||
| 10/31/2015 | Notre Dame | 24 | at | Temple | 20 | @ AAC | ||
| 11/7/2015 | Notre Dame | 42 | at | Pittsburgh | 30 | @ ACC | ||
| 11/14/2015 | Wake Forest | 7 | at | Notre Dame | 28 | ACC | ||
| 11/21/2015 | Notre Dame | 19 | vs | Boston College | 16 | Boston MA | vs ACC | |
| 11/28/2015 | Notre Dame | 36 | at | Stanford | 38 | @ P12 | ||
| 1/1/2016 | Notre Dame | 28 | vs | Ohio State | 44 | Fiesta Bowl (Glendale AZ) | vs B10 |