| 9/5/2015 | Arkansas State (9-4) | 6 | at | Southern California | 55 | SBC | ||
| 9/12/2015 | Idaho (4-8) | 9 | at | Southern California | 59 | SBC | ||
| 9/19/2015 | Stanford (12-2,9-1) | 41 | at | Southern California | 31 | |||
| 9/26/2015 | Southern California | 42 | at | Arizona State (6-7,4-5) | 14 | |||
| 10/8/2015 | Washington (7-6,4-5) | 17 | at | Southern California | 12 | |||
| 10/17/2015 | Southern California | 31 | at | Notre Dame (10-3) | 41 | at ND | ||
| 10/24/2015 | Utah (10-3,6-3) | 24 | at | Southern California | 42 | |||
| 10/31/2015 | Southern California | 27 | at | California (8-5,4-5) | 21 | |||
| 11/7/2015 | Arizona (7-6,3-6) | 30 | at | Southern California | 38 | |||
| 11/13/2015 | Southern California | 27 | at | Colorado (4-9,1-8) | 24 | |||
| 11/21/2015 | Southern California | 28 | at | Oregon (9-4,7-2) | 48 | |||
| 11/28/2015 | UCLA (8-5,5-4) | 21 | at | Southern California | 40 | |||
| 12/5/2015 | Southern California | 22 | vs | Stanford (12-2,9-1) | 41 | P12 Championship (Santa Clara) | ||
| 12/30/2015 | Southern California | 21 | vs | Wisconsin (10-3) | 23 | Holiday Bowl (San Diego CA) | vs B10 |
| vs Southern California | vs Other Opponents | Southern California compared to OOs | |
| Record: | 6-8 | 108-59 | |
| Points Scored: | 25.71 | 35.28 | 9.57 |
| Points Allowed: | 33.93 | 27.28 | 6.65 |
| Margin: | -8.22 | 8.00 | 16.22 |
| Total Points: | 59.64 | 62.56 | -2.92 |