| 9/3/2015 | Oklahoma State | 24 | at | Central Michigan | 13 | @ MAC | ||
| TCU | 23 | at | Minnesota | 17 | @ B10 | |||
| 9/4/2015 | Baylor | 56 | at | SMU | 21 | @ AAC | ||
| 9/5/2015 | Northern Iowa | 7 | at | Iowa State | 31 | MVC (1AA) | ||
| South Dakota State | 41 | at | Kansas | 38 | MVC (1AA) | |||
| South Dakota | 0 | at | Kansas State | 34 | MVC (1AA) | |||
| Texas | 3 | at | Notre Dame | 38 | @ ND | |||
| Akron | 3 | at | Oklahoma | 41 | MAC | |||
| Sam Houston | 45 | at | Texas Tech | 59 | SLC (1AA) | |||
| Georgia Southern | 0 | at | West Virginia | 44 | SBC | |||
| 9/12/2015 | Lamar | 31 | at | Baylor | 66 | SLC (1AA) | ||
| Iowa | 31 | at | Iowa State | 17 | B10 | |||
| Memphis | 55 | at | Kansas | 23 | AAC | |||
| Central Arkansas | 8 | at | Oklahoma State | 32 | SLC (1AA) | |||
| Stephen F. Austin | 7 | at | TCU | 70 | SLC (1AA) | |||
| Oklahoma | 31 | at | Tennessee | 24 | 2OT | @ SEC | ||
| Rice | 28 | at | Texas | 42 | CUSA | |||
| UTEP | 20 | at | Texas Tech | 69 | CUSA | |||
| Kansas State | 30 | at | Texas-San Antonio | 3 | @ CUSA | |||
| Liberty | 17 | at | West Virginia | 41 | BigS (1AA) | |||
| 9/19/2015 | Texas Tech | 35 | at | Arkansas | 24 | @ SEC | ||
| Louisiana Tech | 33 | at | Kansas State | 39 | 3OT | CUSA | ||
| Tulsa | 38 | at | Oklahoma | 52 | AAC | |||
| Texas-San Antonio | 14 | at | Oklahoma State | 69 | CUSA | |||
| SMU | 37 | at | TCU | 56 | AAC | |||
| California | 45 | at | Texas | 44 | P12 | |||
| Iowa State | 23 | at | Toledo | 30 | OT | @ MAC | ||
| 9/26/2015 | Rice | 17 | at | Baylor | 70 | CUSA | ||
| Kansas | 14 | at | Rutgers | 27 | @ B10 | |||
| Oklahoma State | 30 | at | Texas | 27 | ||||
| TCU | 55 | at | Texas Tech | 52 | ||||
| Maryland | 6 | at | West Virginia | 45 | B10 | |||
| 10/3/2015 | Texas Tech | 35 | vs | Baylor | 63 | Arlington TX | ||
| Kansas | 13 | at | Iowa State | 38 | ||||
| West Virginia | 24 | at | Oklahoma | 44 | ||||
| Kansas State | 34 | at | Oklahoma State | 36 | ||||
| Texas | 7 | at | TCU | 50 | ||||
| 10/10/2015 | Baylor | 66 | at | Kansas | 7 | |||
| TCU | 52 | at | Kansas State | 45 | ||||
| Oklahoma | 17 | vs | Texas | 24 | Dallas TX | |||
| Iowa State | 31 | at | Texas Tech | 66 | ||||
| Oklahoma State | 33 | at | West Virginia | 26 | OT | |||
| 10/17/2015 | West Virginia | 38 | at | Baylor | 62 | |||
| TCU | 45 | at | Iowa State | 21 | ||||
| Texas Tech | 30 | at | Kansas | 20 | ||||
| Oklahoma | 55 | at | Kansas State | 0 | ||||
| 10/24/2015 | Iowa State | 27 | at | Baylor | 45 | |||
| Texas Tech | 27 | at | Oklahoma | 63 | ||||
| Kansas | 10 | at | Oklahoma State | 58 | ||||
| Kansas State | 9 | at | Texas | 23 | ||||
| 10/29/2015 | West Virginia | 10 | at | TCU | 40 | |||
| 10/31/2015 | Texas | 0 | at | Iowa State | 24 | |||
| Oklahoma | 62 | at | Kansas | 7 | ||||
| Oklahoma State | 70 | at | Texas Tech | 53 | ||||
| 11/5/2015 | Baylor | 31 | at | Kansas State | 24 | |||
| 11/7/2015 | Iowa State | 16 | at | Oklahoma | 52 | |||
| TCU | 29 | at | Oklahoma State | 42 | ||||
| Kansas | 20 | at | Texas | 59 | ||||
| Texas Tech | 26 | at | West Virginia | 31 | ||||
| 11/14/2015 | Oklahoma | 44 | at | Baylor | 34 | |||
| Oklahoma State | 35 | at | Iowa State | 31 | ||||
| Kansas | 17 | at | TCU | 23 | ||||
| Kansas State | 44 | at | Texas Tech | 59 | ||||
| Texas | 20 | at | West Virginia | 38 | ||||
| 11/21/2015 | West Virginia | 49 | at | Kansas | 0 | |||
| Iowa State | 35 | at | Kansas State | 38 | ||||
| TCU | 29 | at | Oklahoma | 30 | ||||
| Baylor | 45 | at | Oklahoma State | 35 | ||||
| 11/26/2015 | Texas Tech | 48 | at | Texas | 45 | |||
| 11/27/2015 | Baylor | 21 | at | TCU | 28 | 2OT | ||
| 11/28/2015 | Kansas State | 45 | at | Kansas | 14 | |||
| Oklahoma | 58 | at | Oklahoma State | 23 | ||||
| Iowa State | 6 | at | West Virginia | 30 | ||||
| 12/5/2015 | Texas | 23 | at | Baylor | 17 | |||
| West Virginia | 23 | at | Kansas State | 24 | ||||
| 12/29/2015 | North Carolina | 38 | vs | Baylor | 49 | Russell Athletic Bowl (Orlando FL) | vs ACC | |
| LSU | 56 | vs | Texas Tech | 27 | Texas Bowl (Houston TX) | vs SEC | ||
| 12/31/2015 | Oklahoma | 17 | vs | Clemson | 37 | Orange Bowl (Miami FL) | vs ACC | |
| 1/1/2016 | Oklahoma State | 20 | vs | Mississippi | 48 | Sugar Bowl (New Orleans LA) | vs SEC | |
| 1/2/2016 | West Virginia | 43 | vs | Arizona State | 42 | Cactus Bowl (Phoenix AZ) | vs P12 | |
| Kansas State | 23 | vs | Arkansas | 45 | Liberty Bowl (Memphis TN) | vs SEC | ||
| Oregon | 41 | vs | TCU | 47 | 3OT | Alamo Bowl (San Antonio TX) | vs P12 |