| 9/4/2010 | Eastern Illinois | @ | Iowa | ||||||
| 9/11/2010 | Central Arkansas | @ | Eastern Illinois | ||||||
| 9/18/2010 | Eastern Illinois | @ | Tennessee-Martin | OVC | |||||
| 9/25/2010 | Jacksonville St | @ | Eastern Illinois | OVC | |||||
| 10/2/2010 | SE Missouri St | @ | Eastern Illinois | OVC | |||||
| 10/9/2010 | Eastern Illinois | @ | Eastern Kentucky | OVC | |||||
| 10/16/2010 | Eastern Illinois | @ | Tennessee Tech | OVC | |||||
| 10/23/2010 | Murray St | @ | Eastern Illinois | OVC | |||||
| 10/30/2010 | Austin Peay | @ | Eastern Illinois | OVC | |||||
| 11/6/2010 | Eastern Illinois | @ | Tennessee St | OVC | |||||
| 11/13/2010 | Eastern Illinois | @ | Illinois St |