| 9/2/2010 | Eastern Kentucky | @ | Missouri State | ||||||
| 9/11/2010 | Eastern Kentucky | @ | Louisville | ||||||
| 9/18/2010 | Eastern Kentucky | @ | Chattanooga | ||||||
| 10/2/2010 | Kentucky St D2 | @ | Eastern Kentucky | ||||||
| 10/9/2010 | Eastern Illinois | @ | Eastern Kentucky | OVC | |||||
| 10/16/2010 | Eastern Kentucky | @ | Tennessee-Martin | OVC | |||||
| 10/23/2010 | Eastern Kentucky | @ | SE Missouri St | OVC | |||||
| 10/30/2010 | Murray St | @ | Eastern Kentucky | OVC | |||||
| 11/6/2010 | Jacksonville St | @ | Eastern Kentucky | OVC | |||||
| 11/13/2010 | Eastern Kentucky | @ | Tennessee Tech | OVC | |||||
| 11/20/2010 | Austin Peay | @ | Eastern Kentucky | OVC |