| 9/4/2010 | Tennessee Tech | @ | Arkansas | ||||||
| 9/11/2010 | Tennessee Tech | @ | TCU | ||||||
| 9/16/2010 | Lane D2 | @ | Tennessee Tech | ||||||
| 9/25/2010 | Tennessee Tech | @ | SE Missouri St | OVC | |||||
| 9/30/2010 | Tennessee-Martin | @ | Tennessee Tech | OVC | |||||
| 10/9/2010 | Tennessee Tech | @ | Austin Peay | OVC | |||||
| 10/16/2010 | Eastern Illinois | @ | Tennessee Tech | OVC | |||||
| 10/23/2010 | Tennessee Tech | @ | Tennessee St | OVC | |||||
| 11/6/2010 | Tennessee Tech | @ | Murray St | OVC | |||||
| 11/13/2010 | Eastern Kentucky | @ | Tennessee Tech | OVC | |||||
| 11/20/2010 | Jacksonville St | @ | Tennessee Tech | OVC |