| 9/4/2010 | Coastal Carolina 1AA | 0 | @ | West Virginia | 31 | ||||
| 9/10/2010 | West Virginia | 24 | @ | Marshall | 21 | OT | |||
| 9/18/2010 | Maryland | 17 | @ | West Virginia | 31 | ||||
| 9/25/2010 | West Virginia | 14 | @ | LSU | 20 | ||||
| 10/9/2010 | UNLV | 10 | @ | West Virginia | 49 | ||||
| 10/14/2010 | South Florida | 6 | @ | West Virginia | 20 | BigE | |||
| 10/23/2010 | Syracuse | 19 | @ | West Virginia | 14 | BigE | |||
| 10/29/2010 | West Virginia | 13 | @ | Connecticut | 16 | OT | BigE | ||
| 11/13/2010 | Cincinnati | 10 | @ | West Virginia | 37 | BigE | |||
| 11/20/2010 | West Virginia | 17 | @ | Louisville | 10 | BigE | |||
| 11/26/2010 | West Virginia | 35 | @ | Pittsburgh | 10 | BigE | |||
| 12/4/2010 | Rutgers | 14 | @ | West Virginia | 35 | BigE | |||
| 12/28/2010 | West Virginia | 7 | vs | North Carolina State | 23 | Orlando - Champs Sports Bowl |