| 9/2/2010 | Florida A&M 1AA | 0 | @ | Miami-Florida | 45 | ||||
| 9/11/2010 | Miami-Florida | 24 | @ | Ohio State | 36 | ||||
| 9/23/2010 | Miami-Florida | 31 | @ | Pittsburgh | 3 | ||||
| 10/2/2010 | Miami-Florida | 30 | @ | Clemson | 21 | ACC | |||
| 10/9/2010 | Florida State | 45 | @ | Miami-Florida | 17 | ACC | |||
| 10/16/2010 | Miami-Florida | 28 | @ | Duke | 13 | ACC | |||
| 10/23/2010 | North Carolina | 10 | @ | Miami-Florida | 33 | ACC | |||
| 10/30/2010 | Miami-Florida | 19 | @ | Virginia | 24 | ACC | |||
| 11/6/2010 | Maryland | 20 | @ | Miami-Florida | 26 | ACC | |||
| 11/13/2010 | Miami-Florida | 35 | @ | Georgia Tech | 10 | ACC | |||
| 11/20/2010 | Virginia Tech | 31 | @ | Miami-Florida | 17 | ACC | |||
| 11/27/2010 | South Florida | 23 | @ | Miami-Florida | 20 | OT | |||
| 12/31/2010 | Notre Dame | 33 | vs | Miami-Florida | 17 | El Paso - Sun Bowl |