11 Jan 2011 5:05pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | East Carolina | 6-7 |
| L 7-34 at | 9/11/2010 | Southern Miss (7-4) | 10/9/2010 | W 44-43 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Houston | 5-7 |
| L 7-34 at | 9/11/2010 | Southern Miss (6-5) | 11/20/2010 | L 41-59 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Kansas | 3-9 |
| L 7-34 at | 9/11/2010 | Southern Miss (6-5) | 9/17/2010 | L 16-31 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Louisiana Tech | 5-7 |
| L 7-34 at | 9/11/2010 | Southern Miss (6-5) | 9/25/2010 | L 12-13 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Louisville | 7-6 |
| L 7-34 at | 9/11/2010 | Southern Miss (7-4) | 12/21/2010 | W 31-28 vs |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Marshall | 5-7 |
| L 7-34 at | 9/11/2010 | Southern Miss (6-5) | 10/2/2010 | L 16-41 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Memphis | 1-11 |
| L 7-34 at | 9/11/2010 | Southern Miss (6-5) | 10/16/2010 | L 19-41 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | South Carolina | 9-5 |
| L 7-34 at | 9/11/2010 | Southern Miss (7-4) | 9/2/2010 | W 41-13 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Tulane | 4-8 |
| L 7-34 at | 9/11/2010 | Southern Miss (6-5) | 11/6/2010 | L 30-46 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Tulsa | 10-3 |
| L 7-34 at | 9/11/2010 | Southern Miss (7-4) | 11/26/2010 | W 56-50 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | UAB | 4-8 |
| L 7-34 at | 9/11/2010 | Southern Miss (7-4) | 10/30/2010 | W 50-49 2 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | UCF | 11-3 |
| L 7-34 at | 9/11/2010 | Southern Miss (6-5) | 11/13/2010 | L 21-31 |
|