| 4-8 | — | 0 | (1 Common Ops) | 0 | Alabama | 9-3 |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 9/18/2010 | W 62-13 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Arizona | 7-6 |
| L 7-17 at | 9/11/2010 | Southern California (6-5) | 11/13/2010 | L 21-24 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Arizona State | 6-6 |
| L 7-17 at | 9/11/2010 | Southern California (6-5) | 11/6/2010 | L 33-34 at |
|
| 4-8 | — | 0 | (3 Common Ops) | 0 | Army | 7-6 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 9/4/2010 | W 31-27 at |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 9/25/2010 | W 35-21 at |
| W 48-7 | 9/25/2010 | VMI (0-0) | 10/30/2010 | W 29-7 |
| 2-1 | 4-16 | 3-0 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Ball State | 4-8 |
| W 48-21 | 10/23/2010 | Eastern Michigan (1-9) | 10/16/2010 | L 38-41 1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Boise State | 12-1 |
| L 7-37 at | 11/27/2010 | Virginia Tech (10-2) | 9/6/2010 | W 33-30 vs |
|
| 4-7 | — | 0 | (4 Common Ops) | 1 | Boston College | 6-6 |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 9/25/2010 | L 0-19 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 10/16/2010 | L 19-24 at |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 10/23/2010 | L 21-24 |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 11/13/2010 | W 21-16 at |
| 0-4 | 26-19 | 1-3 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Buffalo | 2-10 |
| W 48-21 | 10/23/2010 | Eastern Michigan (1-9) | 11/20/2010 | L 17-21 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | BYU | 7-6 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 9/18/2010 | L 10-34 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | California | 5-7 |
| L 7-17 at | 9/11/2010 | Southern California (6-5) | 10/16/2010 | L 14-48 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Central Michigan | 3-9 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 9/18/2010 | W 52-14 at |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 10/9/2010 | L 21-45 at |
| 1-1 | 11-11 | 1-1 |
|
| 4-8 | — | 0 | (6 Common Ops) | 0 | Clemson | 6-7 |
| W 24-19 | 10/30/2010 | Miami-Florida (6-5) | 10/2/2010 | L 21-30 |
| L 10-44 | 10/16/2010 | North Carolina (6-5) | 10/9/2010 | L 16-21 at |
| L 23-42 | 11/13/2010 | Maryland (8-3) | 10/16/2010 | W 31-7 |
| L 21-33 at | 10/9/2010 | Georgia Tech (5-6) | 10/23/2010 | W 27-13 |
| L 13-17 at | 11/20/2010 | Boston College (5-6) | 10/30/2010 | L 10-16 at |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 11/13/2010 | L 13-16 at |
| 1-5 | 38-29 | 2-4 |
|
| 4-7 | — | 0 | (6 Common Ops) | 1 | Duke | 2-9 |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 10/2/2010 | L 16-21 at |
| W 24-19 | 10/30/2010 | Miami-Florida (6-5) | 10/16/2010 | L 13-28 |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 10/23/2010 | L 7-44 at |
| L 13-17 at | 11/20/2010 | Boston College (5-6) | 11/13/2010 | L 16-21 |
| L 21-33 at | 10/9/2010 | Georgia Tech (4-7) | 11/20/2010 | L 20-30 at |
| L 10-44 | 10/16/2010 | North Carolina (6-5) | 11/27/2010 | L 19-24 |
| 1-5 | 37-30 | 0-6 |
|
| 4-8 | — | 0 | (3 Common Ops) | 0 | East Carolina | 6-7 |
| L 10-44 | 10/16/2010 | North Carolina (6-5) | 10/2/2010 | L 17-42 at |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 12/29/2010 | L 20-51 vs |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 9/18/2010 | L 27-49 at |
| 0-3 | 22-12 | 0-3 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Elon | 0-1 |
| L 48-56 at | 11/6/2010 | Duke (1-9) | 9/4/2010 | L 27-41 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Florida | 8-5 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 11/27/2010 | L 7-31 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Florida A&M | 0-1 |
| W 24-19 | 10/30/2010 | Miami-Florida (6-5) | 9/2/2010 | L 0-45 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Florida Intl | 7-6 |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 9/25/2010 | L 28-42 at |
|
| 4-7 | — | 0 | (5 Common Ops) | 1 | Florida State | 9-4 |
| W 24-19 | 10/30/2010 | Miami-Florida (7-4) | 10/9/2010 | W 45-17 at |
| L 13-17 at | 11/20/2010 | Boston College (6-5) | 10/16/2010 | W 24-19 |
| L 10-44 | 10/16/2010 | North Carolina (6-5) | 11/6/2010 | L 35-37 |
| L 23-42 | 11/13/2010 | Maryland (8-3) | 11/20/2010 | W 30-16 at |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 12/4/2010 | L 33-44 vs |
| 1-4 | 36-20 | 3-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Georgia | 6-7 |
| L 21-33 at | 10/9/2010 | Georgia Tech (5-6) | 11/27/2010 | W 42-34 |
|
| 4-7 | — | 0 | (4 Common Ops) | 1 | Georgia Tech | 5-7 |
| L 10-44 | 10/16/2010 | North Carolina (7-4) | 9/18/2010 | W 30-24 at |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 11/4/2010 | L 21-28 at |
| W 24-19 | 10/30/2010 | Miami-Florida (6-5) | 11/13/2010 | L 10-35 |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 11/20/2010 | W 30-20 |
| 1-3 | 24-20 | 2-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Hawaii | 10-4 |
| L 7-17 at | 9/11/2010 | Southern California (6-5) | 9/2/2010 | L 36-49 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | James Madison | 1-0 |
| L 7-37 at | 11/27/2010 | Virginia Tech (10-2) | 9/11/2010 | W 21-16 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kansas | 3-9 |
| L 21-33 at | 10/9/2010 | Georgia Tech (5-6) | 9/11/2010 | W 28-25 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kent State | 5-7 |
| L 13-17 at | 11/20/2010 | Boston College (5-6) | 9/11/2010 | L 13-26 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | LSU | 11-2 |
| L 10-44 | 10/16/2010 | North Carolina (7-4) | 9/4/2010 | W 30-24 vs |
|
| 4-7 | — | 0 | (4 Common Ops) | 1 | Maryland | 8-4 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 11/20/2010 | L 16-30 |
| W 24-19 | 10/30/2010 | Miami-Florida (6-5) | 11/6/2010 | L 20-26 at |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 10/2/2010 | W 21-16 |
| L 13-17 at | 11/20/2010 | Boston College (6-5) | 10/23/2010 | W 24-21 at |
| 1-3 | 22-22 | 2-2 |
|
| 3-8 | — | 1 | (6 Common Ops) | 0 | Miami-Florida | 7-5 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 10/9/2010 | L 17-45 |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 10/16/2010 | W 28-13 at |
| L 10-44 | 10/16/2010 | North Carolina (7-4) | 10/23/2010 | W 33-10 |
| L 23-42 | 11/13/2010 | Maryland (8-3) | 11/6/2010 | W 26-20 |
| L 21-33 at | 10/9/2010 | Georgia Tech (5-6) | 11/13/2010 | W 35-10 at |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 11/20/2010 | L 17-31 |
| 0-6 | 39-28 | 4-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Miami-Ohio | 10-4 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 9/11/2010 | W 28-21 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Middle Tenn State | 6-7 |
| L 21-33 at | 10/9/2010 | Georgia Tech (4-7) | 10/16/2010 | L 14-42 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Minnesota | 3-9 |
| L 7-17 at | 9/11/2010 | Southern California (6-5) | 9/18/2010 | L 21-32 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Morgan State | 0-1 |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 9/11/2010 | L 3-62 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Navy | 9-4 |
| L 48-56 at | 11/6/2010 | Duke (1-9) | 10/30/2010 | L 31-34 |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 9/6/2010 | L 14-17 vs |
| 0-2 | 8-13 | 0-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Nevada | 13-1 |
| L 13-17 at | 11/20/2010 | Boston College (6-5) | 1/9/2011 | W 20-13 vs |
|
| 4-7 | — | 0 | (5 Common Ops) | 1 | North Carolina | 7-5 |
| L 21-33 at | 10/9/2010 | Georgia Tech (4-7) | 9/18/2010 | L 24-30 |
| W 24-19 | 10/30/2010 | Miami-Florida (6-5) | 10/23/2010 | L 10-33 at |
| L 14-34 | 10/2/2010 | Florida State (9-3) | 11/6/2010 | W 37-35 at |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 11/13/2010 | L 10-26 |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 11/27/2010 | W 24-19 at |
| 1-4 | 30-26 | 2-3 |
|
| 4-8 | — | 0 | (6 Common Ops) | 0 | North Carolina State | 9-4 |
| L 21-33 at | 10/9/2010 | Georgia Tech (5-6) | 9/25/2010 | W 45-28 at |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 10/2/2010 | L 30-41 |
| L 13-17 at | 11/20/2010 | Boston College (6-5) | 10/9/2010 | W 44-17 |
| L 14-34 | 10/2/2010 | Florida State (9-3) | 10/28/2010 | W 28-24 |
| L 10-44 | 10/16/2010 | North Carolina (7-4) | 11/20/2010 | W 29-25 at |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 11/27/2010 | L 31-38 at |
| 0-6 | 43-25 | 4-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Northern Illinois | 11-3 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 11/26/2010 | W 71-3 at |
|
| 4-8 | — | 0 | (3 Common Ops) | 0 | Notre Dame | 8-5 |
| L 13-17 at | 11/20/2010 | Boston College (6-5) | 10/2/2010 | W 31-13 at |
| L 7-17 at | 9/11/2010 | Southern California (7-4) | 11/27/2010 | W 20-16 at |
| W 24-19 | 10/30/2010 | Miami-Florida (7-4) | 12/31/2010 | W 33-17 vs |
| 1-2 | 20-13 | 3-0 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Ohio | 8-5 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 10/2/2010 | W 30-17 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Ohio State | 12-1 |
| W 24-19 | 10/30/2010 | Miami-Florida (7-4) | 9/11/2010 | W 36-24 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 9/25/2010 | W 73-20 |
| 2-0 | 9-12 | 2-0 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Oklahoma | 12-2 |
| L 14-34 | 10/2/2010 | Florida State (9-3) | 9/11/2010 | W 47-17 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Oregon | 12-1 |
| L 7-17 at | 9/11/2010 | Southern California (7-4) | 10/30/2010 | W 53-32 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Oregon State | 5-7 |
| L 7-17 at | 9/11/2010 | Southern California (7-4) | 11/20/2010 | W 36-7 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Pittsburgh | 8-5 |
| W 24-19 | 10/30/2010 | Miami-Florida (6-5) | 9/23/2010 | L 3-31 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Rutgers | 4-8 |
| L 10-44 | 10/16/2010 | North Carolina (6-5) | 9/25/2010 | L 13-17 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Samford | 0-1 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 9/4/2010 | L 6-59 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | South Carolina | 9-5 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 12/31/2010 | L 17-26 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | South Carolina State | 0-1 |
| L 21-33 at | 10/9/2010 | Georgia Tech (4-7) | 9/4/2010 | L 10-41 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | South Florida | 8-5 |
| W 24-19 | 10/30/2010 | Miami-Florida (7-4) | 11/27/2010 | W 23-20 1 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Stanford | 12-1 |
| L 7-17 at | 9/11/2010 | Southern California (7-4) | 10/9/2010 | W 37-35 |
| L 7-37 at | 11/27/2010 | Virginia Tech (10-2) | 1/3/2011 | W 40-12 vs |
| 0-2 | 17-6 | 2-0 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Syracuse | 8-5 |
| L 13-17 at | 11/20/2010 | Boston College (5-6) | 11/27/2010 | L 7-16 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Tennessee | 6-7 |
| L 10-44 | 10/16/2010 | North Carolina (6-5) | 12/30/2010 | L 27-30 2OT vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Toledo | 8-5 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 10/30/2010 | W 42-7 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | UCLA | 4-8 |
| L 7-17 at | 9/11/2010 | Southern California (6-5) | 12/4/2010 | L 14-28 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Vanderbilt | 2-10 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 10/9/2010 | W 52-6 |
|
| 4-7 | — | 0 | (6 Common Ops) | 1 | Virginia Tech | 10-3 |
| L 14-34 | 10/2/2010 | Florida State (9-3) | 12/4/2010 | W 44-33 vs |
| L 21-33 at | 10/9/2010 | Georgia Tech (5-6) | 11/4/2010 | W 28-21 |
| L 10-44 | 10/16/2010 | North Carolina (7-4) | 11/13/2010 | W 26-10 at |
| W 24-19 | 10/30/2010 | Miami-Florida (7-4) | 11/20/2010 | W 31-17 at |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 10/23/2010 | W 44-7 |
| L 13-17 at | 11/20/2010 | Boston College (6-5) | 9/25/2010 | W 19-0 at |
| 1-5 | 36-30 | 6-0 |
|
| 4-8 | — | 0 | (6 Common Ops) | 0 | Wake Forest | 3-9 |
| L 48-56 at | 11/6/2010 | Duke (2-8) | 9/11/2010 | W 54-48 |
| L 14-34 | 10/2/2010 | Florida State (8-4) | 9/25/2010 | L 0-31 at |
| L 21-33 at | 10/9/2010 | Georgia Tech (4-7) | 10/2/2010 | L 20-24 |
| L 7-37 at | 11/27/2010 | Virginia Tech (9-3) | 10/16/2010 | L 21-52 at |
| L 23-42 | 11/13/2010 | Maryland (7-4) | 10/30/2010 | L 14-62 at |
| L 13-17 at | 11/20/2010 | Boston College (5-6) | 11/6/2010 | L 13-23 |
| 0-6 | 35-32 | 1-5 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Washington | 7-6 |
| L 7-17 at | 9/11/2010 | Southern California (7-4) | 10/2/2010 | W 32-31 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Washington State | 2-10 |
| L 7-17 at | 9/11/2010 | Southern California (6-5) | 9/25/2010 | L 16-50 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Weber State | 0-2 |
| L 13-17 at | 11/20/2010 | Boston College (5-6) | 9/4/2010 | L 20-38 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | West Virginia | 9-4 |
| L 23-42 | 11/13/2010 | Maryland (8-3) | 9/18/2010 | W 31-17 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Western Michigan | 6-6 |
| W 48-21 | 10/23/2010 | Eastern Michigan (2-8) | 11/13/2010 | W 45-30 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | William & Mary | 0-1 |
| L 10-44 | 10/16/2010 | North Carolina (6-5) | 10/30/2010 | L 17-21 at |
|