11 Jan 2011 5:04pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Central Michigan | 3-9 |
| L 3-37 at | 9/11/2010 | Northwestern (5-6) | 9/25/2010 | L 25-30 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Illinois | 7-6 |
| L 3-37 at | 9/11/2010 | Northwestern (6-5) | 11/20/2010 | W 48-27 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Indiana | 5-7 |
| L 3-37 at | 9/11/2010 | Northwestern (5-6) | 10/30/2010 | L 17-20 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Iowa | 8-5 |
| L 3-37 at | 9/11/2010 | Northwestern (5-6) | 11/13/2010 | L 17-21 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan State | 11-2 |
| L 3-37 at | 9/11/2010 | Northwestern (6-5) | 10/23/2010 | W 35-27 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Minnesota | 3-9 |
| L 3-37 at | 9/11/2010 | Northwestern (5-6) | 10/2/2010 | L 28-29 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Penn State | 7-6 |
| L 3-37 at | 9/11/2010 | Northwestern (6-5) | 11/6/2010 | W 35-21 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Purdue | 4-8 |
| L 3-37 at | 9/11/2010 | Northwestern (6-5) | 10/9/2010 | W 20-17 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Rice | 4-8 |
| L 3-37 at | 9/11/2010 | Northwestern (5-6) | 9/18/2010 | L 13-30 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Texas Tech | 8-5 |
| L 3-37 at | 9/11/2010 | Northwestern (6-5) | 1/1/2011 | W 45-38 vs |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Vanderbilt | 2-10 |
| L 3-37 at | 9/11/2010 | Northwestern (5-6) | 9/4/2010 | L 21-23 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Wisconsin | 11-2 |
| L 3-37 at | 9/11/2010 | Northwestern (6-5) | 11/27/2010 | W 70-23 |
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