| 9/3/2009 | Illinois St | 6 | @ | Eastern Illinois | 31 | ||||
| 9/12/2009 | Eastern Illinois | 31 | @ | Indiana St | 0 | ||||
| 9/19/2009 | Eastern Illinois | 23 | @ | SE Missouri St | 14 | OVC | |||
| 9/26/2009 | Eastern Illinois | 30 | @ | Austin Peay | 20 | OVC | |||
| 10/3/2009 | Eastern Kentucky | 36 | @ | Eastern Illinois | 31 | OVC | |||
| 10/10/2009 | Eastern Illinois | 3 | @ | Penn State | 52 | ||||
| 10/17/2009 | Tennessee Tech | 15 | @ | Eastern Illinois | 23 | OVC | |||
| 10/24/2009 | Eastern Illinois | 28 | @ | Jacksonville St | 20 | OVC | |||
| 10/31/2009 | Eastern Illinois | 16 | @ | Murray St | 10 | OVC | |||
| 11/14/2009 | Tennessee-Martin | 13 | @ | Eastern Illinois | 49 | OVC | |||
| 11/19/2009 | Tennessee St | 21 | @ | Eastern Illinois | 10 | OVC | |||
| 11/28/2009 | Eastern Illinois | 7 | @ | Southern Illinois | 48 | FCS Playoff round 1 |