| 9/3/2009 | Quincy NAIA | 3 | @ | SE Missouri St | 72 | ||||
| 9/12/2009 | SE Missouri St | 3 | @ | Cincinnati | 70 | ||||
| 9/19/2009 | Eastern Illinois | 23 | @ | SE Missouri St | 14 | OVC | |||
| 9/26/2009 | SE Missouri St | 22 | @ | Tennessee-Martin | 29 | OVC | |||
| 10/3/2009 | SE Missouri St | 17 | @ | Tennessee St | 23 | OVC | |||
| 10/10/2009 | Austin Peay | 24 | @ | SE Missouri St | 14 | OVC | |||
| 10/24/2009 | SE Missouri St | 16 | @ | Tennessee Tech | 28 | OVC | |||
| 10/31/2009 | SE Missouri St | 6 | @ | Eastern Kentucky | 20 | OVC | |||
| 11/7/2009 | Jacksonville St | 24 | @ | SE Missouri St | 3 | OVC | |||
| 11/14/2009 | Murray St | 13 | @ | SE Missouri St | 49 | OVC | |||
| 11/21/2009 | Southern Illinois | 42 | @ | SE Missouri St | 24 |