| 9/3/2009 | Illinois St | 6 | @ | Eastern Illinois | 31 | ||||
| 9/12/2009 | Illinois St | 17 | @ | Illinois | 45 | ||||
| 9/19/2009 | Austin Peay | 7 | @ | Illinois St | 38 | ||||
| 9/26/2009 | S Dakota St | 38 | @ | Illinois St | 17 | MVC | |||
| 10/3/2009 | Illinois St | 27 | @ | N Dakota St | 24 | MVC | |||
| 10/10/2009 | Illinois St | 23 | @ | Southern Illinois | 43 | MVC | |||
| 10/17/2009 | Indiana St | 21 | @ | Illinois St | 38 | MVC | |||
| 10/31/2009 | Illinois St | 24 | @ | Missouri State | 14 | MVC | |||
| 11/7/2009 | Western Illinois | 7 | @ | Illinois St | 25 | MVC | |||
| 11/14/2009 | Illinois St | 18 | @ | Youngstown St | 30 | MVC | |||
| 11/21/2009 | Northern Iowa | 20 | @ | Illinois St | 22 | MVC |