| 9/5/2009 | Southern Illinois | 28 | @ | Marshall | 31 | ||||
| 9/19/2009 | Southwest Baptist D2 | 7 | @ | Southern Illinois | 59 | ||||
| 9/26/2009 | N Dakota St | 14 | @ | Southern Illinois | 24 | MVC | |||
| 10/3/2009 | Southern Illinois | 30 | @ | Western Illinois | 10 | MVC | |||
| 10/10/2009 | Illinois St | 23 | @ | Southern Illinois | 43 | MVC | |||
| 10/17/2009 | Southern Illinois | 27 | @ | Northern Iowa | 20 | MVC | |||
| 10/24/2009 | Youngstown St | 8 | @ | Southern Illinois | 27 | MVC | |||
| 10/31/2009 | Southern Illinois | 33 | @ | Indiana St | 0 | MVC | |||
| 11/7/2009 | Southern Illinois | 34 | @ | S Dakota St | 15 | MVC | |||
| 11/14/2009 | Missouri State | 24 | @ | Southern Illinois | 44 | MVC | |||
| 11/21/2009 | Southern Illinois | 42 | @ | SE Missouri St | 24 | ||||
| 11/28/2009 | Eastern Illinois | 7 | @ | Southern Illinois | 48 | FCS Playoff round 1 | |||
| 12/5/2009 | William & Mary | 24 | @ | Southern Illinois | 3 | FCS Quarterfinals |