| 9/3/2015 | Valparaiso | 10 | at | Eastern Kentucky | 52 | Pio | ||
| Kentucky Wesleyan | 12 | at | Murray State | 52 | D2Ind (D2) | |||
| Eastern Illinois | 5 | at | Western Illinois | 33 | @ MVC | |||
| 9/5/2015 | Mercer | 28 | at | Austin Peay | 7 | SoCon | ||
| Jacksonville State | 23 | at | Chattanooga | 20 | @ SoCon | |||
| Tennessee Tech | 24 | at | Houston | 52 | @ AAC (1A) | |||
| Tennessee-Martin | 3 | at | Mississippi | 76 | @ SEC (1A) | |||
| SE Missouri State | 3 | at | Missouri | 34 | @ SEC (1A) | |||
| 9/6/2015 | Alabama State | 14 | at | Tennessee State | 24 | SWAC | ||
| 9/10/2015 | Bethel TN | 10 | at | Tennessee-Martin | 72 | MSC (NAIA) | ||
| 9/12/2015 | Jacksonville State | 20 | at | Auburn | 27 | OT | @ SEC (1A) | |
| Eastern Kentucky | 0 | at | North Carolina State | 35 | @ ACC (1A) | |||
| Murray State | 26 | at | Northern Illinois | 57 | @ MAC (1A) | |||
| Eastern Illinois | 0 | at | Northwestern | 41 | @ B10 (1A) | |||
| Southern Illinois | 24 | at | SE Missouri State | 27 | MVC | |||
| Austin Peay | 6 | at | Southern Miss | 52 | @ CUSA (1A) | |||
| Jackson State | 25 | vs | Tennessee State | 35 | Memphis TN | vs SWAC | ||
| Tennessee Tech | 14 | at | Wofford | 34 | @ SoCon | |||
| 9/19/2015 | Illinois State | 34 | at | Eastern Illinois | 31 | OT | MVC | |
| SE Missouri State | 28 | at | Indiana State | 29 | @ MVC | |||
| Tennessee State | 13 | at | Jacksonville State | 48 | ||||
| Mercer | 22 | at | Tennessee Tech | 29 | SoCon | |||
| Austin Peay | 7 | at | Vanderbilt | 47 | @ SEC (1A) | |||
| Murray State | 20 | at | Western Michigan | 52 | @ MAC (1A) | |||
| 9/26/2015 | Austin Peay | 13 | at | Eastern Kentucky | 51 | |||
| Tennessee State | 30 | at | Florida A&M | 14 | @ MEAC | |||
| Tennessee Tech | 31 | at | Murray State | 29 | ||||
| Shorter | 26 | at | SE Missouri State | 21 | GSC (D2) | |||
| Jacksonville State | 48 | at | Tennessee-Martin | 41 | ||||
| 10/3/2015 | Eastern Illinois | 40 | at | Austin Peay | 16 | |||
| Mississippi Valley State | 7 | at | Jacksonville State | 49 | SWAC | |||
| Eastern Kentucky | 27 | at | Kentucky | 34 | OT | @ SEC (1A) | ||
| Murray State | 10 | at | SE Missouri State | 27 | ||||
| Tennessee-Martin | 31 | at | Tennessee Tech | 17 | ||||
| 10/8/2015 | Tennessee Tech | 17 | at | Eastern Kentucky | 48 | Georgetown KY | ||
| 10/10/2015 | SE Missouri State | 28 | at | Eastern Illinois | 33 | |||
| Austin Peay | 18 | at | Murray State | 34 | ||||
| Tennessee State | 14 | at | Tennessee-Martin | 28 | ||||
| 10/17/2015 | Tennessee-Martin | 44 | at | Austin Peay | 14 | |||
| Eastern Kentucky | 27 | at | SE Missouri State | 10 | ||||
| Eastern Illinois | 25 | at | Tennessee State | 22 | OT | |||
| Jacksonville State | 42 | at | Tennessee Tech | 13 | ||||
| 10/24/2015 | Jacksonville State | 27 | at | Austin Peay | 7 | |||
| Tennessee Tech | 20 | at | Eastern Illinois | 51 | ||||
| Tennessee State | 21 | at | Eastern Kentucky | 45 | ||||
| Murray State | 45 | at | Tennessee-Martin | 52 | ||||
| 10/31/2015 | Tennessee-Martin | 28 | at | Arkansas | 63 | @ SEC (1A) | ||
| Eastern Kentucky | 0 | at | Jacksonville State | 34 | ||||
| Eastern Illinois | 34 | at | Murray State | 20 | ||||
| Tennessee Tech | 17 | at | SE Missouri State | 38 | ||||
| Austin Peay | 6 | at | Tennessee State | 20 | ||||
| 11/7/2015 | SE Missouri State | 44 | at | Austin Peay | 15 | |||
| Jacksonville State | 24 | at | Eastern Illinois | 3 | ||||
| Tennessee-Martin | 42 | at | Eastern Kentucky | 35 | ||||
| Murray State | 46 | at | Tennessee State | 43 | OT | |||
| 11/14/2015 | SE Missouri State | 28 | at | Jacksonville State | 56 | |||
| Eastern Kentucky | 41 | at | Murray State | 34 | 2OT | |||
| Austin Peay | 24 | at | Tennessee Tech | 42 | ||||
| Eastern Illinois | 23 | at | Tennessee-Martin | 21 | ||||
| 11/21/2015 | Eastern Kentucky | 7 | at | Eastern Illinois | 21 | |||
| Murray State | 20 | at | Jacksonville State | 42 | ||||
| Tennessee-Martin | 28 | at | SE Missouri State | 25 | ||||
| Tennessee State | 24 | at | Tennessee Tech | 30 | ||||
| 11/28/2015 | Eastern Illinois | 17 | at | Northern Iowa | 53 | FCS Playoff Round 1 | @ MVC | |
| 12/5/2015 | Chattanooga | 35 | at | Jacksonville State | 41 | OT | FCS Playoff Round 2 | SoCon |
| 12/11/2015 | Charleston Southern | 38 | at | Jacksonville State | 58 | FCS Quarterfinal | BigS | |
| 12/19/2015 | Sam Houston | 10 | at | Jacksonville State | 62 | FCS Semifinal | SLC | |
| 1/9/2016 | North Dakota State | 37 | vs | Jacksonville State | 10 | FCS National Championship | vs MVC |